Asian Journal of Chemistry and Pharmaceutical Sciences

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Multi-Element Analysis of some Toxic Metals in Urine Using Quadrupole ICP-MS


Affiliations
1 Centro de Informacao e Assistencia Toxicologica (CIATox-Campinas) - Rua Vital Brasil, 251 – Cidade Universitaria Zeferino Vaz. CEP 13083-970, Campinas, SP, Brazil
2 Nucleo de Contaminantes Inorganicos, Centro de Contaminantes, Instituto Adolfo Lutz - Av. Dr. Arnaldo, 355, CEP 01246-000, Sao Paulo, SP, Brazil
 

Occupational and environmental metal contamination is a global concern due to the occurrence of long term health effects in many organ systems. Deficiency or excess of essential metals, depending on personal and/or population nutritional status are also a big public health concern, requiring regular evaluation for early diagnosis and eventual therapeutic intervention. The objective of this study was to validate an easy and rapid analytical method using ICP-MS for the determination of 17 metals (As, Sb - semimetals; Be, Cd, Li, Pb, Pd, Pt, Rh, Sr, Tl, Mn - metals; Mo, Ni, Cr, Cu, Se - essential metals) of toxicological interest. The studied working range demonstrated evidence of linearity and the proposed method proved to be accurate, with good repeatability and intermediate precision. Obtained Limit of Detection (LOD) for the studied analytes were lower or equal to those obtained by CDC in urine.


Keywords

ICP-MS, Metals, Urine, Validation Method.
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  • Multi-Element Analysis of some Toxic Metals in Urine Using Quadrupole ICP-MS

Abstract Views: 384  |  PDF Views: 166

Authors

Paula Christiane Soubhia
Centro de Informacao e Assistencia Toxicologica (CIATox-Campinas) - Rua Vital Brasil, 251 – Cidade Universitaria Zeferino Vaz. CEP 13083-970, Campinas, SP, Brazil
Eduardo Mello De Capitani
Centro de Informacao e Assistencia Toxicologica (CIATox-Campinas) - Rua Vital Brasil, 251 – Cidade Universitaria Zeferino Vaz. CEP 13083-970, Campinas, SP, Brazil
Marcia Liane Buzzo
Nucleo de Contaminantes Inorganicos, Centro de Contaminantes, Instituto Adolfo Lutz - Av. Dr. Arnaldo, 355, CEP 01246-000, Sao Paulo, SP, Brazil
Maria de Fatima Henriques Carvalho
Nucleo de Contaminantes Inorganicos, Centro de Contaminantes, Instituto Adolfo Lutz - Av. Dr. Arnaldo, 355, CEP 01246-000, Sao Paulo, SP, Brazil
Paulo Tiglea
Nucleo de Contaminantes Inorganicos, Centro de Contaminantes, Instituto Adolfo Lutz - Av. Dr. Arnaldo, 355, CEP 01246-000, Sao Paulo, SP, Brazil

Abstract


Occupational and environmental metal contamination is a global concern due to the occurrence of long term health effects in many organ systems. Deficiency or excess of essential metals, depending on personal and/or population nutritional status are also a big public health concern, requiring regular evaluation for early diagnosis and eventual therapeutic intervention. The objective of this study was to validate an easy and rapid analytical method using ICP-MS for the determination of 17 metals (As, Sb - semimetals; Be, Cd, Li, Pb, Pd, Pt, Rh, Sr, Tl, Mn - metals; Mo, Ni, Cr, Cu, Se - essential metals) of toxicological interest. The studied working range demonstrated evidence of linearity and the proposed method proved to be accurate, with good repeatability and intermediate precision. Obtained Limit of Detection (LOD) for the studied analytes were lower or equal to those obtained by CDC in urine.


Keywords


ICP-MS, Metals, Urine, Validation Method.

References