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Alpizar-Ramos, Socorro
- Application of Sequential Design of Experiments to Develop Ibuprofen (400 mg) Tablets by Direct Compression
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Authors
Affiliations
1 School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico, MX
2 Biokinetics, S.A. de C.V., Mexico City, Mexico, MX
1 School of Chemistry, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City, Mexico, MX
2 Biokinetics, S.A. de C.V., Mexico City, Mexico, MX
Source
Asian Journal of Chemistry and Pharmaceutical Sciences, Vol 2, No 1 (2017), Pagination: 10-15Abstract
A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.Keywords
Central-Composite Design, Design Of Experiments, Direct Compression, Ibuprofen, Simplex-Screening Design.Full Text
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