Evaluation of Phytochemicals, Antioxidant and Cytotoxic Activities of Lavandula Antineae Maire Endemic Medicinal Plant from Algeria

The present study was designed to investigate the phytochemical screening, t otal phenolic and flavonoid contents, antioxidant and cytotoxic a ctivities of Lavandula antineae Maire for the first time. Phytochemical screening revealed the presence of a nthraquinones, t riterpenes, s aponins, f lavonoids, t annins, O - heterosides, C - heterosides . Total p henolic and flavonoid contents of the extracts varie d between 12.49 - 262.35 mg GAE/g extract and 1 . 35 - 4 . 03 mg QE/ g extract, respectively. The antioxidant activity was investigated using DPPH, reducing power and β - carotene / linoleic acid tests . The results indicated that ethyl acetate and diethyl ether fractio n s exhibited stronger activities than hydromethanolic crude extract and other fractions. In case of cytotoxicity assay, hydromethanolic extract was found to show good toxicity against brine shrimp nauplii (LC ₅₀ = 13.72 μg/ml )