Asian Journal of Pharmaceutical Research and Health Care

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A UV-Spectrophotmetric Chemometric Method for the Simultaneous Determination of Sulfadoxine and Pyrimethamine in Tablets


Affiliations
1 Northern Border University, Rafha, 91911, PO Box 840, Saudi Arabia
2 KCMS, Khartoum, Sudan
 

In the present study, a simple, inexpensive, precise and accurate uv-spectrophotometric method based on chemometrics, has been developed for the simultaneous determination of sulfadoxine and pyrimethamine in tablet formulation. The % recoveries obtained were 99.7% ± 0.9 and 101.5% ± 0.8 for sulfadoxine and pyrimethamine, respectively. The developed method has been compared to USP-HPLC method with regard to accuracy and precision. The calculated F-ratio and the (t) statistics indicate that there is no significant difference at 5% level with regard to precision and accuracy between the proposed and the USP methods. Moreover, the developed method is simple, cost-effective, and less time-consuming. Accordingly, it can be used advantageously in routine quality control of sulfadoxine and pyrimethamine in tablet formulation.


Keywords

Chemometrics, Pyrimethamine, Simultaneous Determination, Sulfadoxine, Tablets, UV.
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  • A UV-Spectrophotmetric Chemometric Method for the Simultaneous Determination of Sulfadoxine and Pyrimethamine in Tablets

Abstract Views: 422  |  PDF Views: 204

Authors

Hagga M. A. Mohamed
Northern Border University, Rafha, 91911, PO Box 840, Saudi Arabia
Mohd. Imran
Northern Border University, Rafha, 91911, PO Box 840, Saudi Arabia
Monadil H. M. Ali
Northern Border University, Rafha, 91911, PO Box 840, Saudi Arabia
Mohammed F. Abdelwahab
Northern Border University, Rafha, 91911, PO Box 840, Saudi Arabia
Abdullrahman A. Alhaj
KCMS, Khartoum, Sudan

Abstract


In the present study, a simple, inexpensive, precise and accurate uv-spectrophotometric method based on chemometrics, has been developed for the simultaneous determination of sulfadoxine and pyrimethamine in tablet formulation. The % recoveries obtained were 99.7% ± 0.9 and 101.5% ± 0.8 for sulfadoxine and pyrimethamine, respectively. The developed method has been compared to USP-HPLC method with regard to accuracy and precision. The calculated F-ratio and the (t) statistics indicate that there is no significant difference at 5% level with regard to precision and accuracy between the proposed and the USP methods. Moreover, the developed method is simple, cost-effective, and less time-consuming. Accordingly, it can be used advantageously in routine quality control of sulfadoxine and pyrimethamine in tablet formulation.


Keywords


Chemometrics, Pyrimethamine, Simultaneous Determination, Sulfadoxine, Tablets, UV.



DOI: https://doi.org/10.18311/ajprhc%2F2016%2F3965