Simultaneous Estimation and validation of Paracetamol, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in Tablets by Spectrophotometric Method

The present work describes two methods for simultaneous estimation of phenylephrine hydrochloride and chlorpheniramine maleate in pure and solid dosage forms. First method employs the application of simultane ous equation and second, is a multi - wavelength spectrophotometric analysis method. Both methods utilize 0.1N NaOH as solvent. Simultaneous equation develops using 256.8 nm, 236.8 nm and 222.4 nm as the max of paracetamol, phenylephrine hydrochloride and c hlorpheniramine maleate respectively. Calibration curves were linear over the concentration ranges of 0 - 35 μg/mL for all drugs. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 1 %), while be ing simple, cheap and less time consuming, and hence can be suitably applied for simultaneous determination of three drugs in laboratory prepared mixtures and in commercial tablet preparation.