Span-60 Niosomal Oral Suspension of Fluconazole: Formulation and In Vitro Evaluation

Niosomes have shown promise as cheap and chemically stable drug delivery systems. Niosomes have been prepared with different molar rati os of surfactant and cholesterol and their morphological properties have been determine d by scanning electron microscopy. Different batches of Fluconazole niosomal preparations were prepared by changing the surfactant concentration but keeping the cholesterol concentration constant. The surfactant used was Span 60 and the five ba tches of niosomal preparations prepared were in the ratios 1:1:1, 1.5:1:1, 2:1:1, 2.5:1:1 and 3:1:1 (surfactant: cholesterol: drug). Furthermore, the release p rofile, entrapment efficiency, size distribution and stability of these niosomes under various temperatures were studied.