Preparation, Characterization and Evaluation of Hepatoprotective Activity of NNDMAC Biodegradable Parenteral Sustained Release Microspheres

The objective of this work was to prepare biodegradable sustaine d release parenteral microspheres of NNDMA-curcumin (NNDMAC), a novel curcumin analogue , characterize the formulation and evaluate the hepatoprotective activity of the microsphere formulation. Microspheres were prepared using solvent evaporation technique usin g polycaprolactone and were further characterized for various parameters. In vivo animal studies for 10 days were carried out for the determination of hepatoprotective activity of the formul ation in a CCl ₄ model. Particles of 12 μm size with 75.41% yield with no drug-polymer interaction were obtai ned. The drug release was sustained for 10 days. Significant hepatoprotect ion which was better than repeated I.V. administration was offered by the microsphere fo rmulation in this 10-day study. Prepared NNDMAC microspheres have potential use in liver toxicity/ cirrhosis.