Asian Journal of Pharmaceutical Research and Health Care

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Physiological Impact of Statins Experimentally Revealed on Ants


Affiliations
1 27, Square du Castel Fleuri, 1170, Bruxelles, Belgium
2 113, Rue Silvela, 4900, Spa, Belgium
 

Statins are nowadays largely used for caring of persons suffering from hypercholesterolemia. Their use was recently debated. We studied the effects of simvastatin on ants as models. We observed that this product enlarged the insects’ sugar food consumption, reduced their general activity, linear speed, orientation ability, trail following, audacity, tactile and pain perception, cognition, ability in escaping from an enclosure, visual and olfactory conditioning ability (thus their shortterm memory), and their middle term visual and olfactory memory. Simvastatin did not affect the ants’ relationship with their nestmates. The ants developed adaptation to some adverse effects of simvastatine, and presented no habituation to beneficial effects. Also, simvastatine did not lead to dependence. Consequently, even if simvastatin is efficient in reducing the amount of cholesterol, and leads to some adaptation, no habituation and no addiction, it has several harmful effects. This drug should thus be used only in case of high necessity, never for children, and natural alternative with very few adverse effects should be advantageously researched.


Keywords

Cholesterol, Cognition, Food Consumption, Locomotion, Memory.
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  • Versmissen J, Oosterveer DM, Yazdanpanah M, Defesche JC, Basart DC, Liem AH et al. Efficacy of statins in familial hypercholesterolaemia: A long term cohort study [archive]. BMJ. 2008; 337.

  • Armitage J. The safety of statins in clinical practice [archive]. Lancet. 2007; 370:1781–90.

  • Cammaerts M-C. Ants as biological models for studying effects of substances used by humans. JSM Anat Physiol. 2016; 1(1):1003.

  • Cammaerts M-C, Cammaerts R. Ethological and physiological effects of paroxetine, the nowadays most consumed antidepressant. A study on ants as models. Current Topics in Pharmacology. 2016; 12:107–26.

  • Cammaerts M-C, Cammaerts D, Rachidi Z. Potential harmful effects of carbamazepine on aquatic organisms, a study using ants as invertebrate models. Int J Biology. 2015; 7(3):75–93. ISSN 1916-9671 E-ISSN 1916-968X.

  • Wehner R, Gehring W. Biologie et Physiologie Animales. De Boek Université, Thieme Verlag: Paris, Bruxelles; 1999.

  • Wolf FW, Heberlein U. Invertebrate models of drug abuse. J Neurobiol. 2003; 54:161–78.

  • Andre RG, Wirtz RA, Das YT. Insect models for biomedical research. In: Woodhead AD, editor. Non mammalian Animal Models for Biomedical Research. Boca Raton, FL: CRC Press; 1989.

  • Keller RA. A phylogenetic analysis of ant morphology (Hymenoptera: Formicidae) with special reference to the Poneromorph subfamilies. Bull Am Museum Nat Hist. 2011; 355:1–90.

  • Billen J, Morgan ED. Pheromone communication in social insects- sources and secretions. In: Vander Meer RK, Breed MD, Espelie KE, Winston MLK, editors. Pheromone Communication in Social Insects: Ants, Wasps, Bees, and Termites; Westview Press: Boulder, Oxford; 1998.

  • Passera L, Aron S. Les fourmis: comportement, organisation sociale et évolution. Ottawa Canada: Les Presses Scientifiques du CNRC; 2005.

  • Hölldobler B, Wilson EO. The ants. Harvard University Press. Berlin: Springer-Verlag; 1990.

  • Cammaerts M-C, Cammaerts D. Comparative outlook over three Myrmica species’ biotopes and foragers’ knowhow. Biologia. 2014; 69:1051–8.

  • Cammaerts MC, Cammaerts R. Ontogenesis of ants’ cognitive abilities (Hymenoptera, Formicidae). Advanced Studies in Biology. 2015; 7:335–48 + synopsis: 349–50.

  • Cammaerts MC, Gosset G. Impact of age, activity and diet on the conditioning performance in the ant Myrmica ruginodis used as a biological model. Int J Biol. 2014; 6: 10-20. ISSN 1916-9671 E-ISSN 1916-968X

  • Cammaerts M-C, Dero A, Cammaerts R. Stevia: A true glycoside used as a sweetener and not affecting behavior. Asian J Pharm Res Healthcare. 2016; 8(1):19–31.

  • Cammaerts M-C, Cammaerts R, Rachidi Z. Effects of four plants extract used as an anxiolytic: A study on ants as models. Adv Biomed Pharma. 2016; 3(5):280–95.

  • Siegel S, Castellan NJ. Non-parametric statistics for the behavioural sciences. Singapore: McGraw-Hill Book Company; 1989.

  • Cammaerts MC, Morel F, Martino F, Warzée N. An easy and cheap software-based method to assess two-dimensional trajectories parameters. Belg J Zool. 2012; 142:145–51.

  • Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM. Statinassociated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy. 2003; 23:871–80.

  • Sathasivam S, Lecky B. Statin induced myopathy [archive]. BMJ. 2008; 337.

  • Cammaerts MC. Adverse effects of a natural product allowing decreasing the amount of cholesterol in blood: A study using ants as models. MOJ Biol Med. 2017; 1(3):00013.


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  • Physiological Impact of Statins Experimentally Revealed on Ants

Abstract Views: 391  |  PDF Views: 166

Authors

Marie-Claire Cammaerts
27, Square du Castel Fleuri, 1170, Bruxelles, Belgium
David Cammaerts
113, Rue Silvela, 4900, Spa, Belgium

Abstract


Statins are nowadays largely used for caring of persons suffering from hypercholesterolemia. Their use was recently debated. We studied the effects of simvastatin on ants as models. We observed that this product enlarged the insects’ sugar food consumption, reduced their general activity, linear speed, orientation ability, trail following, audacity, tactile and pain perception, cognition, ability in escaping from an enclosure, visual and olfactory conditioning ability (thus their shortterm memory), and their middle term visual and olfactory memory. Simvastatin did not affect the ants’ relationship with their nestmates. The ants developed adaptation to some adverse effects of simvastatine, and presented no habituation to beneficial effects. Also, simvastatine did not lead to dependence. Consequently, even if simvastatin is efficient in reducing the amount of cholesterol, and leads to some adaptation, no habituation and no addiction, it has several harmful effects. This drug should thus be used only in case of high necessity, never for children, and natural alternative with very few adverse effects should be advantageously researched.


Keywords


Cholesterol, Cognition, Food Consumption, Locomotion, Memory.

References





DOI: https://doi.org/10.18311/ajprhc%2F2017%2F15977