Asian Journal of Pharmaceutical Research and Health Care

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miRNA-141 as the Biomarker for Human Cancers


Affiliations
1 University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam
2 Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Viet Nam
 

microRNA (miRNA) is considered to be a pivotal role in human numerous biological process, and their abnormal expression that functions either as tumor suppressor or oncogenes results in human cancer initiation and development microRNA-141 (miR-141), belonged to the miR-200 family, located at 12p13.31 and is also found to be abundantly expressed in many human cancers. Additionally, Prognostic and predictive miR-141 signatures have been defined for a variety of cancer types. This review summarized the biogenesis and processing of miRNA, as well as the roles of miR-141 in human cancer pathways, its targets and the potential utility of miR-141 as prognostic biomarkers.

Keywords

Biomarker, Human Cancer, microRNA, microRNA-141.
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  • miRNA-141 as the Biomarker for Human Cancers

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Authors

Thuan Duc Lao
University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam
Phuong Kim Truong
Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Viet Nam
Thuy Ai Huyen Le
Department of Pharmaceutical and Medical Biotechnology, Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Viet Nam

Abstract


microRNA (miRNA) is considered to be a pivotal role in human numerous biological process, and their abnormal expression that functions either as tumor suppressor or oncogenes results in human cancer initiation and development microRNA-141 (miR-141), belonged to the miR-200 family, located at 12p13.31 and is also found to be abundantly expressed in many human cancers. Additionally, Prognostic and predictive miR-141 signatures have been defined for a variety of cancer types. This review summarized the biogenesis and processing of miRNA, as well as the roles of miR-141 in human cancer pathways, its targets and the potential utility of miR-141 as prognostic biomarkers.

Keywords


Biomarker, Human Cancer, microRNA, microRNA-141.

References





DOI: https://doi.org/10.18311/ajprhc%2F2018%2F21486