miRNA-141 as the Biomarker for Human Cancers

microRNA (miRNA) is considered to be a pivotal role in human numerous biological process, and their abnormal expression that functions either as tumor suppressor or oncogenes results in human cancer initiation and development microRNA-141 (miR-141), belonged to the miR-200 family, located at 12p13.31 and is also found to be abundantly expressed in many human cancers. Additionally, Prognostic and predictive miR-141 signatures have been defined for a variety of cancer types. This review summarized the biogenesis and processing of miRNA, as well as the roles of miR-141 in human cancer pathways, its targets and the potential utility of miR-141 as prognostic biomarkers.