Asian Journal of Pharmaceutical Research and Health Care

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Unusual Localised Skin Reaction due to Ondansetron: Case Series


Affiliations
1 Department of Pharmacology, Smt B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, India
2 Department of Paediatric, GMERS Medical College, Gotri, Vadodara – 390021, Gujarat, India
3 Department of Pharmacology, Nootan Medical College and Research Centre, Sankalchand Patel University, Visnagar – 384315, Gujarat, India
4 Department of Physiology, Smt B.K Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, India
 

Ondansetron is an antiemetic drug that belongs to 5-hydroxytryptamine (5-HT3) receptor antagonists group. It has been widely used to treat nausea and vomiting due to chemotherapy, post surgery or due to any other gastrointestinal problem with 5-HT3 receptors involvement. The typical adverse drug reactions of Ondansetron include headache, dizziness, constipation or diarrhoea. Here, we have observed the skin reaction around the site of injection following Ondansetron administration. Recognition of this hypersensitivity reaction may allow better preparedness of clinicians to manage this condition.


Keywords

Ondansetron, 5-HT3, Skin Reaction.
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  • Varshney RK, Jain G. Localized urticaria with intravenous ondansetron: A case report with literature review. Acta Medica International 2014;1(1):39-40.

  • Alame MM, Chamsy DJ, Zaraket H. Pityriasis rosea-like eruption associated with ondansetron use in pregnancy. Br J Clin Pharmacol. 2018;84(5):1077-1080. doi:10.1111/bcp.13560

  • Mori-Vogt S, Blazer M. Palonosetron for the prevention of chemotherapyinduced nausea and vomiting. Expert Rev Anticancer Ther. 2013;13:919-36. doi: 10.1586/14737140.2013.814412. PubMed PMID: 23984894.

  • Singhal AK, Kannan S, Gota VS. 5HT3 antagonists for prophylaxis of postoperative nausea and vomiting in breast surgery: a meta-analysis. J Postgrad Med. 2012;58:23-31. PubMed PMID: 22387645.

  • Finn AL. Toxicity and side eff ects of ondansetron. Semin Oncol. 1992; 19(4): 53-60.

  • Russell D,Kenny GNC. 5HT3 antagonists in postoperative nausea and vomiting. Br J Anaesth 1992; 69:63-68.

  • Sharma A, Raina V. Generalised seizures following Ondansetron. Ann Oncol 2001; 12(1):131-2.

  • Tolan MM, Fuhrman TM, Tsueda K, Lippmann SB: Perioperative extrapyramidal reactions associated with Ondansetron. Anesthesiology 1999; 90:340-1.

  • Mehra KK, Gogtay NJ, Ainchwar R, Bichile LS. Hypersensitivity to intravenous ondansetron: a case report. J Med Case Rep. 2008;2:274. Published 2008 Aug 14. doi:10.1186/1752-1947-2-274

  • Sharma A, Raina V: Generalised seizures following Ondansetron. Ann Oncol 2001, 12(1):131-132.

  • Ondansetron: drug information - UpToDate [Internet]. Available at: https%3A%2F%2Fwww.uptodate.com%2Fcontents%2Fondansetron-drug information%3Fsource%3Dsearch_result%26amp%3Bsearch%3Dondansetron%26amp%3BselectedTitle% 3D1~132 (last accessed 3 July 2020).


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  • Unusual Localised Skin Reaction due to Ondansetron: Case Series

Abstract Views: 483  |  PDF Views: 1676

Authors

Shruti Brahmbhatt
Department of Pharmacology, Smt B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, India
Vihang Brahmbhatt
Department of Paediatric, GMERS Medical College, Gotri, Vadodara – 390021, Gujarat, India
Nehal Shah
Department of Pharmacology, Nootan Medical College and Research Centre, Sankalchand Patel University, Visnagar – 384315, Gujarat, India
Mahavirsingh Rajput
Department of Physiology, Smt B.K Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, India

Abstract


Ondansetron is an antiemetic drug that belongs to 5-hydroxytryptamine (5-HT3) receptor antagonists group. It has been widely used to treat nausea and vomiting due to chemotherapy, post surgery or due to any other gastrointestinal problem with 5-HT3 receptors involvement. The typical adverse drug reactions of Ondansetron include headache, dizziness, constipation or diarrhoea. Here, we have observed the skin reaction around the site of injection following Ondansetron administration. Recognition of this hypersensitivity reaction may allow better preparedness of clinicians to manage this condition.


Keywords


Ondansetron, 5-HT3, Skin Reaction.

References





DOI: https://doi.org/10.18311/ajprhc%2F2021%2F27967