Asian Journal of Pharmaceutical Research and Health Care

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Analysis of Prescribing Pattern, Efficacy and Adverse Drug Reactions of Anti-diabetic Agents in Type-2 Diabetic Patients at a Tertiary Care Teaching Hospital


Affiliations
1 Department of Pharmacology, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh
2 Department of Pharmacology, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh, India
3 Department of Medicine, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh, India
 

Prescription pattern analysis provides guidance to utilize available drugs rationally. Diabetes is a chronic, hyperglycaemic metabolic disorder with subsequent complications. The aim of present study is to analyse prescribing pattern, efficacy and Adverse Drug Reactions (ADRs) of Anti-diabetic Drugs (ADDs) in our tertiary care teaching institute. A prospective analytical study was conducted and demographical details, investigations (fasting, postprandial blood glucose and HbA1C at every 3 months, LFT, Lipid profile and KFT) and prescriptions were collected from 135 uncomplicated Type-2 diabetic patients visiting Medicine OPD over a period of 18 months. Prescriptions were collected and ADDs, fixed dose combinations (FDCs), other medicines used and ADRs were also recorded. Data collected was analysed using t-test and chi-square test. 94 (69.63%) patients were of 41-60 years age group with mean BMI of 26.63 ± 3.26. Fasting, postprandial blood glucose and HbA1c initially and at 18 months were 193 ± 65, 284 ± 78, 9.2 ± 2.3 and 107 ± 15, 163 ± 23, 6.5 ± 0.6 respectively with a significant reduction in mean fasting, postprandial blood glucose and HBA1c at 18 months (P<0.0001). Total drugs prescribed were 331, ADDs 222 (67.07%), FDCs 61 (18.43%), generic drugs 270 (81.57%), drugs from National list of Essential Medicines 259 (78.25%), injectables 2 (1.48%), other group of drugs 48 (14.50%) and ADRs 21 (15.56%). Average drugs per prescription were 2.45 and ADDs 1.64. The present study showed that the prescriptions were rational, drugs used were efficacious and ADRs mild and transient.

Keywords

Antidiabetic Drugs, NLEM, Prescribing Pattern
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  • Sutharson L, Hariharan RS, Vamsadhara C. Drug utilization study in diabetology outpatient of a tertiary hospital. Indian J Pharmacol. 2003; 35:237–40.

  • DiPiro, J, Talbert, R, Yee G, Matzke G, Wells B, Posey L, Streetman D, Streetman D. Book Review: Pharmacotherapy: A Pathophysiologic Approach, 7th Ed. Annals of Pharmacotherapy. 2009; 43(2):395-395. https://doi.org/10.1345/aph.1L477

  • Bhanu P, Prasanand S, Divyashanthi CM, Annabelle R, Pandiamunian J. Prescribing pattern and WHO core prescribing indicators in post-operative patients of gynaecology department of tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2017; 6:53–60.

  • American Diabetes Association. Standards of medical care in diabetes-2019. Diagnosis and classification of Diabetes mellitus. Diabetes Care. 2019; 42:S13–29. PMid: 30559228. https://doi.org/10.2337/dc19-S002

  • Raphael M, Vijayanarayana K, Thunga G, Rao NK, Sreedharan N. Utilization pattern of anti-diabetic drugs in Type-2 Diabetes Mellitus in Tertiary Care Hospital. Res J Pharm Technol. 2017; 10:2063–8. https://doi.org/10.5958/0974-360X.2017.00360.2

  • Anilasree BP, Sreekumar S, Nazeer N, Husna P. Drug utilization evaluation of anti diabetic therapy with Type-2 Diabetes Mellitus of a tertiary care hospital in Calicut. J Med Pharm Allied Sci. 2019; 8:2235–53. https://doi.org/10.22270/jmpas.v8i3.841

  • Shrestha JT, Shrestha H, Prajapati M, Karkee A, Maharjan A. Adverse effects of oral hypoglycemic agents and adherence to them among patients with Type-2 Diabetes Mellitus in Nepal. JLMC. 2017; 5:34–40. https://doi.org/10.22502/ jlmc.v5i1.126

  • Agarwal AA, Jadhav PR, Deshmukh YA. Prescribing pattern and efficacy of anti-diabetic drugs in maintaining optimal glycemic levels in diabetic patients. J Basic Clin Pharm. 2014; 5:79–83. PMid: 25278671 PMCid: PMC4160724. https://doi.org/10.4103/0976-0105.139731

  • Chu WM, Ho HE, Huang KH, Tsan YT, Liou YS, Wang YH et al. The prescribing trend of oral antidiabetic agents for Type-2 diabetes in Taiwan. Medicine. 2017; 96(43):e8257. PMid: 29068991 PMCid: PMC5671824. https://doi. org/10.1097/MD.0000000000008257

  • Bhavana P, Kumar VS, Divya N, Pratheek KP, Rao GE. Assessment of the prescription pattern of oral hypoglycemic drugs in uncomplicated Diabetic Mellitus patients at tertiary care hospital. IJPSR. 2018; 9(8):3487–92.

  • Pankaj CK, Satendra SP, Dhananjay P, Kumud R, Rajmangal C, Bhanu P. A prospective study on drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital of eastern Uttar Pradesh, India. Int J Res Med Sci. 2019; 7:669. https://doi.org/10.18203/2320-6012.ijrms20190915

  • Sharma T, Sahai R, Bala S, Dhasmana DC, Kaeley N. Prescribing pattern of oral anti-diabetic agents in Type-2 Diabetes Mellitus patients in a tertiary care hospital. Int J Basic Clin Pharmacol. 2018; 7:956. https://doi.org/10.18203/2319-2003.ijbcp20181642

  • Mani G, Neelam R. Investigation of outpatient prescribing pattern of antidiabetic drugs in Type -2 diabetic patients - a study conducted at a tertiary care hospital. IOSR J Phar Bio Sci. 2015; 10:26–30.

  • Karthikeyan V, Maadhusudhan S, Selvamuthukumran S. Studies on prescribing pattern in the management of Diabetes Mellitus in rural teaching hospital. Saudi J Med Pharm Sci. 2016; 2:100–7.

  • Mahmood M, Reddy RC, Lahari JR S, Fatima S, Shinde P, Reddy S A et al. Prescription pattern analysis of antidiabetic drugs in Diabetes Mellitus and associated comorbidities. Clin Inves (Lond). 2017; 8:5–12. https://doi.org/10.4172/ Clinical-Investigation.1000123

  • Sasisekhar TV, Shabana S, Bhargav SY. Gender: Does it have role has role in glycemic control and diabetes distress in Type-2 diabetes. IOSR-JDMS. 2013; 4: 48–51. https://doi. org/10.9790/0853-0464851

  • Ashutosh K, Ipseeta RM, Sandeep R. Assessment of prescription pattern of antidiabetic drugs in the outpatient department of a tertiary care hospital. Int J Clin Endocrinal Metab. 2017; 3:1–7. https://doi.org/10.17352/ijcem.000021

  • Muthukumar A, Sridevi M, Gayathri R, Sundar MS, Ganapathy A, Mohan RS. Pharmacovigilance study of antidiabetic drugs in hypertensive patients in a territory hospital in Coimbatore zone. Scholars Research Library Der Pharmacia Lettre. 2017; 9:70–6.

  • Alex SM, Sreelekshmi BS, Smitha S, Jiji KN, Menon AS, Uma Devi P. Drug utilization pattern of anti-diabetic drugs among diabetic outpatients in a tertiary care hospital. Asian J Pharm Clin Res. 2015; 8:144–6.

  • Dominic A, Joseph J, Augustin RM, Begum R, Nanjwade BK, et al. Study of drug use evaluation on oral antihyperglycemic agents in Type-2 Diabetes Mellitus and their potential drug-drug interactions. Int J Clin Endocrinal Metab. 2016; 5:1884–96.


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  • Analysis of Prescribing Pattern, Efficacy and Adverse Drug Reactions of Anti-diabetic Agents in Type-2 Diabetic Patients at a Tertiary Care Teaching Hospital

Abstract Views: 240  |  PDF Views: 108

Authors

Avneesh Kumar
Department of Pharmacology, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh
Asha Pathak
Department of Pharmacology, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh, India
Alok Dixit
Department of Pharmacology, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh, India
Manoj Kumar
Department of Medicine, Uttar Pradesh University of Medical Sciences Saifai, Etawah – 206130, Uttar Pradesh, India

Abstract


Prescription pattern analysis provides guidance to utilize available drugs rationally. Diabetes is a chronic, hyperglycaemic metabolic disorder with subsequent complications. The aim of present study is to analyse prescribing pattern, efficacy and Adverse Drug Reactions (ADRs) of Anti-diabetic Drugs (ADDs) in our tertiary care teaching institute. A prospective analytical study was conducted and demographical details, investigations (fasting, postprandial blood glucose and HbA1C at every 3 months, LFT, Lipid profile and KFT) and prescriptions were collected from 135 uncomplicated Type-2 diabetic patients visiting Medicine OPD over a period of 18 months. Prescriptions were collected and ADDs, fixed dose combinations (FDCs), other medicines used and ADRs were also recorded. Data collected was analysed using t-test and chi-square test. 94 (69.63%) patients were of 41-60 years age group with mean BMI of 26.63 ± 3.26. Fasting, postprandial blood glucose and HbA1c initially and at 18 months were 193 ± 65, 284 ± 78, 9.2 ± 2.3 and 107 ± 15, 163 ± 23, 6.5 ± 0.6 respectively with a significant reduction in mean fasting, postprandial blood glucose and HBA1c at 18 months (P<0.0001). Total drugs prescribed were 331, ADDs 222 (67.07%), FDCs 61 (18.43%), generic drugs 270 (81.57%), drugs from National list of Essential Medicines 259 (78.25%), injectables 2 (1.48%), other group of drugs 48 (14.50%) and ADRs 21 (15.56%). Average drugs per prescription were 2.45 and ADDs 1.64. The present study showed that the prescriptions were rational, drugs used were efficacious and ADRs mild and transient.

Keywords


Antidiabetic Drugs, NLEM, Prescribing Pattern

References