The Asian Journal of Experimental Chemistry

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Complexes of Transition Metals with Tridentate N-(2-Thiazole) Benzamide-2'-Carboxylic Acid and Oxine


Affiliations
1 Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
2 Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
3 Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
4 Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India
     

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Complexes of the type [ ML2 ] and [ MLL'.H2O ] [ where, M = Cu(II), Ni(II), Co(II), Zn(II) and Mn(II); HL = N-(2-thiazole)-2'-carboxylic acid; and L' = oxine] have been synthesized. The complexes are octahedral in nature. The synthesized ligand behaves as tridendate OON donor. The characterization of the complexes has been done on the basis of analytical, molar conductance, magnetic susceptibility, molecular weight, infrared and electronic spectral data. Antibacterial activity of these ligands and their metal complexes has been determined on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria at 37°C and antifungal activity has been determined on common fungi viz., Aspergillus niger, Aspergillus nidulense and Candida albicans at 28°C. It has been found that the biocidal activity of these ligands increases on being coordinated with suitable metal ion.

Keywords

I.R./Electronic, Spectra/Mixed, Ligand Complexes/Ternary, Complexes/Metal Chelates.
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  • Complexes of Transition Metals with Tridentate N-(2-Thiazole) Benzamide-2'-Carboxylic Acid and Oxine

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Authors

Rajesh Nagar
Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
Govind Mohan
Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
Anugya Mehta
Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
Arvind Kumar
Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India

Abstract


Complexes of the type [ ML2 ] and [ MLL'.H2O ] [ where, M = Cu(II), Ni(II), Co(II), Zn(II) and Mn(II); HL = N-(2-thiazole)-2'-carboxylic acid; and L' = oxine] have been synthesized. The complexes are octahedral in nature. The synthesized ligand behaves as tridendate OON donor. The characterization of the complexes has been done on the basis of analytical, molar conductance, magnetic susceptibility, molecular weight, infrared and electronic spectral data. Antibacterial activity of these ligands and their metal complexes has been determined on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria at 37°C and antifungal activity has been determined on common fungi viz., Aspergillus niger, Aspergillus nidulense and Candida albicans at 28°C. It has been found that the biocidal activity of these ligands increases on being coordinated with suitable metal ion.

Keywords


I.R./Electronic, Spectra/Mixed, Ligand Complexes/Ternary, Complexes/Metal Chelates.