The Asian Journal of Experimental Chemistry

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Complexes of Diphenyl Amine Mercapto Carboxylic Acid:A New Anti-Inflammatory Agent


Affiliations
1 Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
2 Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
3 Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
4 Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India
     

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Diphenyl amine-2-mercapto-2'-carboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. In acute anti-inflammatory test Cu(II) complex was found to be more potent than Ibuprofen in normal and adrenalectomized rats but less effective in subacute and chronic anti-inflammatory tests. It inhibited PGE2 like substance ( 25%) and Castor oil induced diarrhoea (30%) but did not protect the mice against arachidonic acid induced mortality. However, it had very low degree of gastric irritation but without analgesic effect.

Keywords

Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.
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  • Complexes of Diphenyl Amine Mercapto Carboxylic Acid:A New Anti-Inflammatory Agent

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Authors

Rajesh Nagar
Ministry of Commerce and Industry (Govt. of India), Chemical Road, Dhrangadhra (Gujarat), India
Govind Mohan
Department of Pharmacology, S.N. Medical College, Agra (U.P.), India
Anugya Mehta
Thrombosis Research Unit, Sree Chitra Tirumal Institute for Medical Science and Technology, Biomedical Technological Wing, Thiruvananthapuram (Kerala), India
Arvind Kumar
Department of Chemistry, Narayan P.G. College, Shikohabad (U.P.), India

Abstract


Diphenyl amine-2-mercapto-2'-carboxylic acid and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized and characterized by their elemental analyses, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. In acute anti-inflammatory test Cu(II) complex was found to be more potent than Ibuprofen in normal and adrenalectomized rats but less effective in subacute and chronic anti-inflammatory tests. It inhibited PGE2 like substance ( 25%) and Castor oil induced diarrhoea (30%) but did not protect the mice against arachidonic acid induced mortality. However, it had very low degree of gastric irritation but without analgesic effect.

Keywords


Metal Complex, NSAID’s, Prostaglandins, Anti Inflammatory Agent.