The Asian Journal of Experimental Chemistry

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Estimation of Drotaverine in Bulk and Pharmaceutical Formulations by Precipitation Reagents


Affiliations
1 Department of Chemistry, GITAM Institute of Technology, GITAM University, Visakhapatnam (A.P.), India
2 Department of Chemistry, GIT Institute of Technology, GITAM University, Visakhapatnam (A.P.), India
     

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Three simple accurate visible sepectrophotometric methods (A.B and C) have been developed for the estimation of Drotaverine (DRT) in bulk and pharmaceutical formulations. The estimation was done based on its complex formation with alkaloids using spectrophotometric methods. Drotaverine forms a molecular complex with SNP (Sodium Nitro Prusside) in method-A, CTC (Cobalt thiocyanate) in method B and DDQ (2,3-dichloro-dicyano-1,4-benzoquinone) in method C during its quantitative precipitation. The absorbance of nitrobenzene layer was measured at the respective wavelength of maximum absorbance against the reagent blank. To determine Drotaverine colour reaction was used in addition to precipitation reaction. They are based on the colour formation with either unreacted precipitant of the filtrate or released precipitant from the molecular complex. All the variables have been optimized. The proposed methods are validated statistically. Recovery studies were carried out by standard addition method.

Keywords

Drotaverine, SNP, CTC, DDQ and Spectrophotometer.
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  • Estimation of Drotaverine in Bulk and Pharmaceutical Formulations by Precipitation Reagents

Abstract Views: 188  |  PDF Views: 2

Authors

G. Himavathi
Department of Chemistry, GITAM Institute of Technology, GITAM University, Visakhapatnam (A.P.), India
M. Kiranmai Reddy
Department of Chemistry, GIT Institute of Technology, GITAM University, Visakhapatnam (A.P.), India

Abstract


Three simple accurate visible sepectrophotometric methods (A.B and C) have been developed for the estimation of Drotaverine (DRT) in bulk and pharmaceutical formulations. The estimation was done based on its complex formation with alkaloids using spectrophotometric methods. Drotaverine forms a molecular complex with SNP (Sodium Nitro Prusside) in method-A, CTC (Cobalt thiocyanate) in method B and DDQ (2,3-dichloro-dicyano-1,4-benzoquinone) in method C during its quantitative precipitation. The absorbance of nitrobenzene layer was measured at the respective wavelength of maximum absorbance against the reagent blank. To determine Drotaverine colour reaction was used in addition to precipitation reaction. They are based on the colour formation with either unreacted precipitant of the filtrate or released precipitant from the molecular complex. All the variables have been optimized. The proposed methods are validated statistically. Recovery studies were carried out by standard addition method.

Keywords


Drotaverine, SNP, CTC, DDQ and Spectrophotometer.