Asian Journal of Pharmaceutical Analysis

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Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix


Affiliations
1 Gujarat Technological University, Gujarat, India
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, India
     

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Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.

Keywords

Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.
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  • Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix

Abstract Views: 305  |  PDF Views: 3

Authors

Paras Virani
Gujarat Technological University, Gujarat, India
Rajanit Sojitra
Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, India
Hasumati Raj
Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, India
Vineet Jain
Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, India

Abstract


Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.

Keywords


Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.