Asian Journal of Pharmaceutical Analysis

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Spectrophotometric Determination of and Validation of Zidovudine Concentration in Bulk and Dosage Form


Affiliations
1 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal-Trimbakeshwar, Dist- Nashik, Maharashtra, India
2 Dept. of Pharmaceutical Chemistry, M.V.P's College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India
     

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A simple, accurate, precise, sensitive and a highly selective ultra violet spectrophotometric method has been developed for the simultaneous estimation of in bulk and solid dosage form. The estimation of Zidovudine was carried out at 266 nm. The developed method was validated for linearity, range, precision, recovery studies and interference study for mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in marketed formulations.

Keywords

Zidovudine, UV- Method, Spectrometric Method, Determination.
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  • Spectrophotometric Determination of and Validation of Zidovudine Concentration in Bulk and Dosage Form

Abstract Views: 314  |  PDF Views: 2

Authors

Ghanshyam B. Jadhav
KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal-Trimbakeshwar, Dist- Nashik, Maharashtra, India
Amar G. Zalte
KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal-Trimbakeshwar, Dist- Nashik, Maharashtra, India
Ravindranath B. Saudagar
KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal-Trimbakeshwar, Dist- Nashik, Maharashtra, India
Ashok P. Pingale
Dept. of Pharmaceutical Chemistry, M.V.P's College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India

Abstract


A simple, accurate, precise, sensitive and a highly selective ultra violet spectrophotometric method has been developed for the simultaneous estimation of in bulk and solid dosage form. The estimation of Zidovudine was carried out at 266 nm. The developed method was validated for linearity, range, precision, recovery studies and interference study for mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in marketed formulations.

Keywords


Zidovudine, UV- Method, Spectrometric Method, Determination.