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Extractive Spectrophotometric Method for Determination of Aripiprazole Hydrochloride in Bulk and Pharmaceutical Formulations


Affiliations
1 Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, India
2 Krishna Teja Pharmacy College, Tirupati, India
     

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Four simple and sensitive spectrophotometric methods (A - D) for the assay of Aripiprazole in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference.
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  • Extractive Spectrophotometric Method for Determination of Aripiprazole Hydrochloride in Bulk and Pharmaceutical Formulations

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Authors

Mohan Krishna Lokireddy
Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, India
P. Jayachandra Reddy
Krishna Teja Pharmacy College, Tirupati, India
Nallathambi Ramasamy
Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, India
B. Prabhakar Reddy
Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, India

Abstract


Four simple and sensitive spectrophotometric methods (A - D) for the assay of Aripiprazole in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference.