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Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form


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1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
     

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Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.
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  • Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form

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Authors

N. Santhi
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
S. S. Rajendran
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
P. Kumar Nallasivan
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
W. D. Sam Solomon
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
R. Venkata Narayanan
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India

Abstract


Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords


Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.