Asian Journal of Pharmaceutical Analysis

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form


Affiliations
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
     

   Subscribe/Renew Journal


Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 339

PDF Views: 0




  • Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form

Abstract Views: 339  |  PDF Views: 0

Authors

N. Santhi
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
S. S. Rajendran
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
P. Kumar Nallasivan
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
W. D. Sam Solomon
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India
R. Venkata Narayanan
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, India

Abstract


Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords


Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.