Asian Journal of Pharmaceutical Analysis

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Development and Validation of a Spectrophometric Method for Estimation of Triamcinolone in Solid Dosage form


Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), India
     

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The new simple, sensitive, accurate, precise, rapid and economical method was developed for the estimation of Triamicinolone in solid dosage form. Method is based on the absorbance. Triamcinolone maximum is found at 238 nm in methanol water solvent. The linearity was obtained in the concentration range of 3-9 mcg/ml with coefficient of correlation 0.9998. The value of ruggedness and robustness was found to be 0.2182 and 0.43 respectively. The method is found to be accurate, precise and useful in quality control of dosage form.

Keywords

Triamcinolone, Spectrophotometric and Validation
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  • Development and Validation of a Spectrophometric Method for Estimation of Triamcinolone in Solid Dosage form

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Authors

Shiv Kumar Gupta
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Babita Kumar
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Pramod Kumar Sharma
School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), India

Abstract


The new simple, sensitive, accurate, precise, rapid and economical method was developed for the estimation of Triamicinolone in solid dosage form. Method is based on the absorbance. Triamcinolone maximum is found at 238 nm in methanol water solvent. The linearity was obtained in the concentration range of 3-9 mcg/ml with coefficient of correlation 0.9998. The value of ruggedness and robustness was found to be 0.2182 and 0.43 respectively. The method is found to be accurate, precise and useful in quality control of dosage form.

Keywords


Triamcinolone, Spectrophotometric and Validation

References