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Authors
Affiliations
1 Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, IN
2 Krishna Teja Pharmacy College, Tirupati, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 4 (2013), Pagination: 127-130
Abstract
Four simple and sensitive spectrophotometric methods (A - D) for the assay of Aripiprazole in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer's law and the precision and accuracy of the methods are checked by the UV reference.
