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Kumar, Babita
- Development and Validation of a RP-HPLC Method for Estimation of Thalidomide in Solid Dosage form
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Authors
Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), ID
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), ID
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 1 (2013), Pagination: 17-19Abstract
A simple, rapid and precise isocratic reverse phase High Performance Liquid Chromatographic method has been developed for the determination of Thalidomide capsule. The separation was achieved with 150×4.6mm C18 column using mobile phase as Acetonitrile: Dimethyl Formamide : Water (60:10:30 v/v) at a flow rate of 1.0ml/min with UV detection at 297nm. The retention time of Thalidomide was found to be 2.17min. The linearity range of Thalidomide is 25mg to 200mg with coefficient of correlation 0.9986. The method is found to be accurate, precise and useful in quality control of dosage form.Keywords
RP–HPLC, Thalidomide, Method Development and Validation
References
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- Singh RM Shivraj Mathur SC Singh GN Sharma PK and Gupta SK Method development and its validation of Drug Thalidomide in API usinf RP-HPLC method. Journal of Indian Council of Chemist. 22(2); 2006: 25-27.
- Singh S Singh UK Singh RM Singh GN Mathur SC Saini PK Yadav A Gupta V and Duggal D Development and validation of a RP-HPLC method for estimation of prulifloxacin in tablet dosage form. Indian Journal of Pharmaceutical Science. 73(5); 2011: 557.
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- Development and Validation of a Spectrophometric Method for Estimation of Triamcinolone in Solid Dosage form
Abstract Views :401 |
PDF Views:0
Authors
Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
2 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 2 (2013), Pagination: 42-43Abstract
The new simple, sensitive, accurate, precise, rapid and economical method was developed for the estimation of Triamicinolone in solid dosage form. Method is based on the absorbance. Triamcinolone maximum is found at 238 nm in methanol water solvent. The linearity was obtained in the concentration range of 3-9 mcg/ml with coefficient of correlation 0.9998. The value of ruggedness and robustness was found to be 0.2182 and 0.43 respectively. The method is found to be accurate, precise and useful in quality control of dosage form.Keywords
Triamcinolone, Spectrophotometric and ValidationReferences
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- Gupta SK Kumar B and Sharma PK Development and validation of a RP-HPLC method for estimation of Thalidomide in solid dosage form. Asian Journal of Pharmaceutical Analysis. 3(1); 2013: 17-19.
- Singh RM Shivraj Mathur SC Singh GN Sharma PK and Gupta SK Method development and its validation of Drug Thalidomide in API using RP-HPLC method. Journal of Indian Council of Chemist. 22(2); 2006: 25-27.
- Singh S Singh UK Singh RM Singh GN Mathur SC Saini PK Yadav A Gupta V and Duggal D Development and validation of a RP-HPLC method for estimation of prulifloxacin in tablet dosage form. Indian Journal of Pharmaceutical Science. 73(5); 2011: 557.
- International Conference on Harmonisation, (1996) Guidance for Industry in: Q2B Validation on Analytical Procedures. Methodology Switzerland IFPMA, 1.
- Spectrophotometric Estimation of Dextromethorphan in Bulk Drug using Hydrotropic Solubilization Technique
Abstract Views :914 |
PDF Views:1
Authors
Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 3 (2013), Pagination: 90-93Abstract
A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10-120μg/ml with coefficient of correlation 0.9993.The % RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.Keywords
Dextromethorphan, Hydrotropic Study, Enhancement of Solubility, Method Development and ValidationReferences
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- Chemical Analysis Case Study of Underground Water in Hapur (West)
Abstract Views :254 |
PDF Views:5
Authors
Affiliations
1 Sanskar College of Pharmacy and Research, Opp. Jindal Pipes Ltd., NH-24, Ghaziabad (U.P.) 201302, IN
1 Sanskar College of Pharmacy and Research, Opp. Jindal Pipes Ltd., NH-24, Ghaziabad (U.P.) 201302, IN