Asian Journal of Pharmaceutical Analysis

Abstract

Compatibility must be established between the active ingredient and other excipients to produce a stable efficacious, attractive and safe product.

In this report FTIR studies were performed and major peaks were determined by the (FTIR-8400S Shimadzu, Japan) will show band shift and broadening compared to the spectra of pure drug. To study the interaction between AmbroxolHCl, selected excipients (sorbitol, mannitol, sucrose).IR spectra of Ambroxol hydrochloride bands were found at 1595-1545 cm^-1 for aromatic C=C stretching, 3350-3250cm^-1 for aromatic primary amine NH stretch, 3400-3345 cm^-1 for intermolecular hydrogen bonded OH stretch and 700-600 cm^-1 for C-Br stretching. This confirms the identity of Ambroxol hydrochloride.

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