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Raj, Hasumati
- Development and Validation of Analytical Method for Clopidogrel Bisulphate and Irbesartan by Simultaneous Equation Spectroscopic Method
Abstract Views :193 |
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Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 2 (2016), Pagination: 102-108Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Clopidogrel Bisulphate and Irbesartan in synthetic mixture using simultaneous equation Method. In this spectroscopic method, for Clopidogrel Bisulphate 220.00 nm and 250.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 10-50 μg/ml at their respective λmax with correlation coefficient (r2) of 0.9996 and 0.9998 for Clopidogrel Bisulphate and Irbesartan, respectively. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (< 2%). The limit of determination was 0.243 μg/ml and 0.323 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. The limit of quantification was 0.737 μg/ml and 0.980 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. Recovery of Clopidogrel Bisulphate and Irbesartan were found to be 99.57 % and 99.68 % respectively confirming the accuracy of the proposed method. % Assay was found to be 99.41 % and 99.22 % for Clopidogrel Bisulphate and Irbesartan, respectively. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Clopidogrel Bisulphate, Irbesartan, Simultaneous Estimation, Validation Method.- Development and Validation of Analytical Method for Aripiprazole and Escitalopram Oxalate by Simultaneous Equation Spectroscopic Method
Abstract Views :193 |
PDF Views:2
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 41-46Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Aripiprazole and Escitalopram Oxalate in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 255.00 nm and 238.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 5-30 μg/ml and 15-75 μg/ml at their respective λmax. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.129 and 0.223μg/ml Aripiprazole and Escitalopram Oxalate, respectively. The limit of quantification was 0.392 and 0.677 for Aripiprazole and Escitalopram Oxalate, respectively. Recovery of Aripiprazole and Escitalopram Oxalate in were found to be 100.66 % and 100.70 % respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Aripiprazole, Escitalopram Oxalate, Simultaneous Estimation, Simultaneous Equation Method, Analysis Method.- Candesartan Cilexetil: A Review of Spectroscopic and Chromatographic Method
Abstract Views :193 |
PDF Views:2
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 53-58Abstract
Candesartan Cilexetil is classified as an AT1 Angiotensin II receptor antagonist as a Antihypertensive agent. There are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and Pharmcodynamic and pharmacokinetic studies as well as stability study. There are many article examines published analytical methods reported so far in the literature for the determination of Candesartan Cilexetil in biological samples and pharmaceutical formulations. These article comprise reviews of analytical methods like Spectrophotometric methods, Chromatographic method including HPLC, HPTLC.Keywords
Candesartan Cilexetil, Spectrophotometry, HPLC, Anti-Hypertensive Agent, AT1 Angiotensin II Receptor Antagonist.- Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix
Abstract Views :228 |
PDF Views:3
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 151-160Abstract
Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.Keywords
Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.- Simultaneous Estimation of Irbesartan and Atorvastatin by Q Absorption Ratio Method in Their Synthetic Mixture
Abstract Views :227 |
PDF Views:0
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN