Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Pandya, M. K.
- Q-Analysis Spectrophotometric Method for the Simultaneous Determination of Nabumetone and Paracetamol in API and in Tablet Dosage form
Abstract Views :657 |
PDF Views:1
Authors
Affiliations
1 Xylopia, Ahmadabad, IN
2 R.K University, Rajkot, IN
3 B. K. Mody Govt. Pharmacy College, Rajkot, IN
1 Xylopia, Ahmadabad, IN
2 R.K University, Rajkot, IN
3 B. K. Mody Govt. Pharmacy College, Rajkot, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 1 (2013), Pagination: 9-16Abstract
A simple, sensitive and rapid Q-Analysis spectrophotometric method has been developed for simultaneous estimation of Nabumetone and Paracetamol from tablets. Here, absorbance is measured at two wavelengths. One being the max of Paracetamol (248.4 nm) and other being a wavelength of equal absorptivity of two components (238.6 nm) i.e. an isoabsorptive point. Linearity of response was observed in concentration range of 2-30 μg/ml for Nabumetone and 2-20 μg/ml for Paracetamol. The results of method were validated statically and by recovery studies. The % recovery was found to be 98.09% to 100.23% for Nabumetone whereas 99.88% to 101.81% for Paracetamol. The results of analysis in terms of % label claim was 98.72% ± 0.42 for Nabumetone and 101.62% ± 0.26 for Paracetamol for a formulation analyzed. The developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of Nabumetone and Paracetamol in tablets.Keywords
Q–Analysis Spectrophotometric Method, Nabumetone, Paracetamol, Methanol, Isoabsorptive Point
References
- Current Index of Medical Specialties, Update Prescribers Handbook published by CMP Medica India Pvt. Ltd., Bangalore, 117-119, 263, Jul-Oct 2007.
- Merck Index, Merck Research Laboratories, division of Merck and company NJ, 13th ed., pp. 1088, 2001.
- United State Pharmacopoeia 26, NF 21, pp. 1259, 2003.
- Indian Pharmacopoeia (4th ed.), vol.-2, Govt. of India, Ministry of Health and Family Welfare, Controller of Publications, New Delhi. 554, 1996.
- K. Kobylinska, M. Barlinska and M. Kobylinska, “Analysis of nabumetone in human plasma by HPLC. Application to single dose pharmacokinetic studies”, J Pharm Biomed Anal, vol. 32, pp. 323-28, 2003.
- E. Mikami, T. Goto, T. Ohno, H. Matsumoto and M. Nishida, “Simultaneous analysis of naproxen, nabumetone and its major metabolite 6- methoxy-2-naphthylacetic acid in pharmaceuticals and human urine by high-performance liquid chromatography”, J Pharm Biomed Anal, vol. 23, no. 5, pp. 917-925, 2000.
- F. Idrees and Al-Momani, “Determination of Nabumetone and Its Major Metabolite in Plasma and Tablet Formulations by Reverse-Phase HPLC ”, Analytical Letters, vol. 30, no. 14, pp. 2485 – 92, 1997.
- A. Kumar, B. Anroop and K. S. Vijay, “Spectrophotometric method for the simultaneous estimation of nimesulide and paracetamol in tablet dosage form”, Indian Drugs, vol. 40, no.12, pp. 727-29, 2003.
- J. F. Sheen, G. R. Her, “Application of pentafluorophenyl hydrazine derivatives to the analysis of Nabumetone and testosterone in human plasma by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry”, Anal Bioanal Chem, vol. 380, no.7-8, pp. 891-7, 2004.
- R. Szotak and s. Mazurek, “Quantitative determination of acetylsalicylic acid and paracetamol in tablet dosage form”, The Analyst, vol. 127, pp. 144-48, 2002.
- P. R. Mahaparle, J. N. Sangshetti, S. V. Deshpande and P. V. Kasture, “Simultaneous spectro-photometric estimation of aceclophenac and paracetamol in tablet dosage form”, Indian J. Pharma. Educ. Res, vol. 41, no. 1, 42-45, 2007.
- S. Ravishankar, M. Vasudevan and S. Mathew, “Spectrophotometric method for the simultaneous estimation of paracetamol and chlormezanone in formulations”, Indian Drugs, vol. 35, no.5, pp. 306- 8, 1998.
- M Knochen, J Giglio and B. F. Reis, “Flow injection spectrophotometric determination of paracetamol in tablets and oral solutions”, J. Pharma. Biomed. Anal, vol. 33, 191-7, 2003.
- V. Nagulwar, Y. Dhurvey, S. Despande, K. Upadhye, S. Bakhle, and R. Wadetwar, “UV Spectroscopic estimation of paracetamol and valdecoxib in tablet dosage fo rm”, Indian J. Pharm. Sci, vol. 68, no. 5, 639-40, 2006.
- J. T. Franeta, D. Agbaba and S. Eric, “HPLC assay of acetylsalicylic acid, paracetamol, caffeine and Phenobarbital”, Pharmaco, vol. 57, 709-13, 2002.
- V. M. Shinde and R. Raman, “Simultaneous method for determination of paracetamol and chlormezanone in tablets by RP-HPLC ”, Indian Drugs, vol. 35, no. 8, pp. 521-23, 1998.
- U. B. Halkar, P. B. Analkope and S. H. Rane, “High performance liquid chromatographic method for the determination of paracetamol, caffe ine and propyphenazone in tablets”, Indian Drugs, vol. 39, no. 5, pp. 293-96, 2002.
- M. Y. Momin, P. G. Yeole and M. P. Puranik, “RP-HPLC method for the determination of paracetamol and aceclophenac in tablet dosage form”, Ind. J. Pharm. Sci, vol. 68, no.3, pp. 387- 89, 2006.
- A. Karthik, A. Subramanian, N. Udupa, “Simultaneous RPHPLC estimation of Paracetamol and Domperidone in tablets”, Indian J. Pharm. Sci, vol. 69, no.1, pp. 142-43, 2007.
- S. Natarajan, B. Raman, “Stability indicating Isocratic HPLC method for simultaneous estimation of Ondasetron Hydrochloride and Paracetamol from tablets dosage”, Indian Drug, vol. 45, no.5, 2008.
- M. K. Chouksey, A. Kandapur, N. Tyagi, G. Singh, “Simultaneous estimation of Paracetamol, Chlorzoxazone and Diclofenac sodium in solid dosage forms by RP-HPLC ”, Method Indian Drug, vol. 43, no. 3, 2006.
- B. S. Nagaralli, J. Seetharamappa, B. G. Gowda and M. B. Melwanki, "Liquid chromatographic determination of ceterizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations”, Journal of Chromatography B, vol. 798, no. 1, pp.49–54, 2003.
- A. Eswaraselvam, “Simultaneous estimation of paracetamol and ibuprofen by RP-HPLC by using same mobile phase for assay and dissolution in tablet dosage form”, I.P.C. Abstracts, pp. 83, 2004.
- G. Subramanian, Simultaneous RP-HPLC estimation of Tizanidine, Diclofenac potassium and Paracetamol in tablets, Indian J. Pharm. Sci., vol. 66, no.5, pp. 694-96, 2004.
- A. S. Bhavsar, G. S. Talele, R. A. Fursule and S. J. Surana, “RP-HPLC estimation of paracetamol and valdecoxib in combined dosage form”, Indian J. Pharm. Sci vol. 68, no. 5,pp. 675-77, 2006.
- C. Celema, J. A. Alluue, J. Prunonosa, C. Peraire and R Obach, “ simultaneous determination of Paracetamol and Chlorpheniramine in human plasma by liquid chromatography tandem mass spectrometery”, Journal of Chromatography Analysis, vol. 870, no.1-2, pp. 77-86, 2000.
- S Azagvuel and R. Sekar, “Method development and validation for the simultaneous determination of cetrizine dihydrochloride, paracetamol and phenylpropanolamine hydrochloride in tab- lets by capillary zone electrophoresis”, J. Pharm. Biomed. Anal, no. 1-6, 2006.
- International Conference on Harmonization (1994) Harmonized Tripartite Guideline, Validation Analytical Procedures, Text and Methodology Q2 (R1), ICH, Geneva, Switzerland.
- Dual Wavelength Spectrophotometric Method for the Simultaneous Determination of Paracetamol and Nabumetone in API and in Tablet Dosage Form
Abstract Views :215 |
PDF Views:0
Authors
Affiliations
1 Xylopia, Ahmadabad, IN
2 R.K University, Rajkot, IN
3 B. K. Mody Govt. Pharmacy College, Rajkot, IN
1 Xylopia, Ahmadabad, IN
2 R.K University, Rajkot, IN
3 B. K. Mody Govt. Pharmacy College, Rajkot, IN