Asian Journal of Pharmaceutical Analysis

J. Anu Deepa ¹, N. Santhi ¹, R. Ramya ¹, R. Siva Kumar ¹, R. Venkata Narayanan ¹

Affiliations
1 R.V.S College of Pharmaceutical Sciences, Sulur, Coimbatore – 641 402, IN

Abstract

A new simple, sensitive and precise visible spectrophotometric method has been developed for the determination of Secnidazole in bulk and in pharmaceutical formulation. This method is based on the reduction of secnidazole, in the presence of 4N Hydrochloric acid and ethanol to form yellow colored chromogen. Which was estimated at an absorption maximum of 477.5 nm. This method has the linearity in the concentration range of 100-500μg/ml. This method is statistically evaluated for efficacy.

Keywords

Secnidazole, Reduction Method.

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N. Santhi ¹, S. S. Rajendran ¹, P. Kumar Nallasivan ¹, W. D. Sam Solomon ¹, R. Venkata Narayanan ¹

Affiliations
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN

Abstract

Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.

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S. S. Rajendran ¹, N. Santhi ¹, P. Kumar Nallasivan ¹, W. D. Sam Solomon ¹, R. Venkata Narayanan ¹

Affiliations
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN

Abstract

Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.

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N. Santhi ¹, Deepthi ¹, S. S. Rajendran ¹, S. Gananadhamu ¹, G. Devala Rao ¹, Sai Lohit ¹

Affiliations
1 K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada, IN

Abstract

A new simple, sensitive and precise visible spectrophotometric method has been developed for the determination of ziprasidone in bulk and in pharmaceutical formulations. This method is based on the hydrolysis of Ziprasidone, followed by diazotization and coupling with N-(1-naphthyl) ethylene diamine dihydrochloride to form an azo dye which was estimated at an absorption maximum of 540nm (pink color). This method has the linearity in the concentration range of 2-10 μg/ml. This method is statistically evaluated for efficacy.

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