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Authors
Affiliations
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra-431112, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 142-146
Abstract
Venlafaxine belongs to a group of Antidepressant with a novel chemical structure. In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of absorbance of Venlafaxine hydrochloride solution in 0.1N NaOH at 225 nm. The method obeys Beer's Lambert's law in the selected concentration range 5-25 μg/ml in selected solvent. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of venlafaxine hydrochloride in bulk and pharmaceutical formulations.
Keywords
UV-Visible Spectrophotometer, Method Development, Venlafaxine Hydrochloride.
