Asian Journal of Pharmaceutical Analysis

N. Santhi ¹, S. S. Rajendran ¹, P. Kumar Nallasivan ¹, W. D. Sam Solomon ¹, R. Venkata Narayanan ¹

Affiliations
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN

Abstract

Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.

Full Text

     

S. S. Rajendran ¹, N. Santhi ¹, P. Kumar Nallasivan ¹, W. D. Sam Solomon ¹, R. Venkata Narayanan ¹

Affiliations
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN

Abstract

Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.

Keywords

Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.

Full Text