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Padmavathi, Y.
- Development of Sensitive Spectrophotometric Method for Analysis of Darifenacin Hydrobromide Liposomes in Rat Plasma
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Authors
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, G. Pulla Reddy College of Pharmacy, Osmania University, Mehdipatnam, Hyderabad, Telangana, IN
1 Department of Pharmaceutical Analysis and Quality Assurance, G. Pulla Reddy College of Pharmacy, Osmania University, Mehdipatnam, Hyderabad, Telangana, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 1 (2017), Pagination: 41-47Abstract
A new simple and sensitive visible spectrophotometric method for the estimation of darifenacin hydrobromide (DHB) liposomes was developed using diazo coupling reagent, 3-amino phenol in spiked rat plasma. Spectrophotometric method was developed using diazo coupling reaction with the chromogenic reagent, 3-amino phenol for estimation of darifenacin hydrobromide in liposomes. 3-amino phenol forms a yellow colored diazo complex with darifenacin hydrobromide in acidic conditions. The color intensity range was found to be linear in the concentration range of 100-1000ng/mL. Analysis was carried out at its λmax 438nm. The method was validated according to ICH guidelines. The method was optimized and validated in spiked rat plasma according to USFDA guidelines. The developed method was simple and sensitive and the LOQ value was found to be 100ng/mL. All the validation parameters were found to be within the acceptable limits. As the method was sensitive, it was successfully applied to the analysis of darifenacin hydrobromide liposomes in spiked rat plasma.Keywords
3-Amino Phenol, Darifenacin Hydrobromide, ICH Guidelines and USFDA Guidelines.
- Development and Validation of Difference Spectrophotometric Method for the Quantitative Estimation of Mesalamine in Bulk Drug and Dosage Forms
Abstract Views :589 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, G. Pulla Reddy College of Pharmacy, Osmania University, Mehdipatnam, Hyderabad, Telangana, IN
1 Department of Pharmaceutical Analysis and Quality Assurance, G. Pulla Reddy College of Pharmacy, Osmania University, Mehdipatnam, Hyderabad, Telangana, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 4 (2017), Pagination: 225-228Abstract
A sensitive, precise, economic spectrophotometric method i.e. a difference spectroscopic method was developed for the estimation of mesalamine in bulk and dosage (tablet and suppository) forms. Difference spectroscopic method was developed by measuring the difference absorbance of the drug in 0.1N HCl and in 0.1 N NaOH showing maximum absorbance at 330nm. Beer’s law was obeyed in the concentration range of 5-25 μg/ml. The LOD and LOQ were found to be 0.3 μg/ml and 0.9 μg/ml respectively. Correlation coefficient was observed as 0.999. The method was validated as per ICH guideline Q2R1 and the results were within the official limits. The developed difference spectroscopic method was applied for quantitative analysis of the drug in bulk and pharmaceutical dosage forms.Keywords
Mesalamine, COX Inhibitor, Difference Spectroscopic Method, ICH Guidelines.References
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