Bi-Layer Tablet System-An Innovative Trend

Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains fundamentals of bilayer tablet system which includes application, advantages, disadvantages, various techniques of bilayer tablet system, various type of bilayer tablet press currently available in the market, various approaches used in bilayer tablet system, characterization as well as evaluation of the bilayer tablet system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet.