Asian Journal of Pharmaceutical Research

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SERM’s in Treatment of Breast Cancer


Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., India
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, India
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, India
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, India
5 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India
     

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Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.

Keywords

Selective Estrogen Receptor Modulators (SERM’s), Breast Cancer, Hormone Replacement Therapy (HRT).
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  • SERM’s in Treatment of Breast Cancer

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Authors

Ravindra B. Saudagar
Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., India
Nachiket S. Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, India
Deepak S. Musmade
Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, India
Vinayak M. Gaware
Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, India
D. A. Jain
Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, India

Abstract


Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.

Keywords


Selective Estrogen Receptor Modulators (SERM’s), Breast Cancer, Hormone Replacement Therapy (HRT).