Development and In Vitro Evaluation Colon Targeted Drug Delivery System Using Natural Gums

The present study deals with formulation of sustained release tablet of ibuprofen for colon targeting. Tablets were prepared using combination of guar and xanthan gum. The drug excipient interaction studies were carried out by FTIR and DSC. The prepared matrixes (GG :XG, 4:6) form enzyme controlled delivery systems with nearly 50 to 60% w/w of the tablet content being constituted by polysaccharides degradable by colonic microflora. Biodegradability studies of guar and xanthan gum was carried out in presence of 4% w/v RCC and galactomannase enzyme (0.1 mg/ml.) by viscosity measurement using Brookfield viscometer and significant decrease in viscosity was found with 4% RCC after 24 h incubation. In vitro drug release studies shows that guar and xanthan gum in 4:6 has optimum release in a controlled manner for 24 h.