Asian Journal of Pharmaceutical Research

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Microwave-Assisted Synthesis, Characterization and Biological Activity of Novel Pyrazole Derivatives


Affiliations
1 Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India
2 Medicinal Chemistry Research Lab, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, India
3 Department Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu-523167, Andhra Pradesh, India
4 Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, India
     

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A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde 4a-e has been synthesized and tested for their anti-inflammatory and analgesic activities. Formation of the pyrazole derivatives was achieved by treating vilsmeier-haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to indomethacin, flufenamic acid and diazepam as standard drugs. The detailed synthesis, spectroscopic and toxicity data are reported.

Keywords

Pyrazole, Anti-Inflammatory Activity, Analgesic Activity.
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  • Microwave-Assisted Synthesis, Characterization and Biological Activity of Novel Pyrazole Derivatives

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Authors

T. Panneer Selvam
Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India
G. Saravanan
Medicinal Chemistry Research Lab, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, India
C. R. Prakash
Department Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu-523167, Andhra Pradesh, India
P. Dinesh Kumar
Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, India

Abstract


A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde 4a-e has been synthesized and tested for their anti-inflammatory and analgesic activities. Formation of the pyrazole derivatives was achieved by treating vilsmeier-haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to indomethacin, flufenamic acid and diazepam as standard drugs. The detailed synthesis, spectroscopic and toxicity data are reported.

Keywords


Pyrazole, Anti-Inflammatory Activity, Analgesic Activity.