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Recent Advance in Gastroretantive Drug Delivery System (GRDDS)
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The drug delivery system is most important and preferable drug delivery system. This route has high patient acceptability, primarily due to easy of administration. Effective oral drug delivery depends upon the factors such as gastric emptying process, the gastrointestinal transit time of the dosage form drug release from the dosage form, and site of absorption of drug. In recent years, scientific and technological advancements have been made in the research and development of gastro retentive drug delivery systems. Hence forth a wide spectrum of dosage forms has been developed for the drugs which have narrow absorption window, unstable at intestinal pH, are soluble in acidic pH, and have a site of action specific to stomach. The purpose of writing this review was to investigate, compile and present the recent as well as past literature in a more concise way with a special focus on approaches that are currently utilized in the prolongation of gastric residence time. These include floating system, swelling and expanding system, bio/mucoadhesive system, high-density system, and other delayed gastric emptying devices. The present review addresses briefly the classification, formulation consideration for Gastroretantive drug delivery system (GRDDS), factors controlling gastric retention, merits, demerits, and applications of gastro retentive drug delivery systems.
Keywords
Gastro retentive drug delivery system, floating system, swelling, expanding system, bio/mucoadhesive system, high-density system, H Pylori infection and its Application
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- Basak SC, Rao NK, Manavalan R, Rao RP. Development and invitro evaluation of an oral floating matrix tablet formulation of ciprofloxacin. IJPS, 2004;66(3):313-316.
- Streubel A, Siepmann, Bodmeir J. Drug delivery to the upper intestine window using gastroretentive technologies. Curr Opin Pharmacol, 2006:6:501-508.
- Chen YC, Ho H, Lee TY, Sheu MT. Physical characterizations and sustained release profiling of gastroretentive drug delivery system with improved floating and swelling capabilities. International Journal Of Pharmaceutics, 2013;44: 162-169.
- Prajapati DV, Jani GK, Khutliwala TA, Zala BS. Raft forming system- An upcoming approach of gastroretentive drug delivery system. Journal of Controlled Release, 2013; 168:151-165.
- Subhramananyam CVS, Setty JT. Laboratory manual of physical Pharmaceutics. Vallabh Prakashan 2002; pg no 212.
- Vinod KR, Vasa S, Anbuazagahan S. Approaches for gastroretentive drug delivery, IJABPT, 2008;589-601.
- Pawar V.K, Shaswat K, Garg G, Awasthi R. Gastroretentive dosage form: A review with special emphasis on floating drug delivery systems, Informa Healthcare 2011;18(2):97-110
- Dixit N. Floating drug delivery system. Journal of Current Pharmaceutical Research, 2011;7(1):6-20.
- Robinson J, Lee R. Controlled Drug Delivery, 2 nd edition, 1987: pg 418.
- Bardonnet PL, Faivre V, Pugh WJ, Piffaretti JC, Falson F. Gastroretentive dosage forms. Journal of Controlled Release, 2006; 111:1-18.
- Arora S, Javed A, Ahuja A, Khar RK, Baboota S. Floating drug delivery system: a review. AAPS Pharm Sci Tech, 2000;6(3):372- 390.
- Patel GM, Patel HR, and Patel M. Floating drug delivery system an innovative approach to prolong gastric retention. Pharmainfo.net 2007
- Arora S, Javed A, Ahuja A, Khar RK, Baboota S. Floating drug delivery system: a review. AAPS Pharm Sci Tech, 2000;6(3):372- 390.
- Patel GM, Patel HR, and Patel M. Floating drug delivery system an innovative approach to prolong gastric retention. Pharmainfo.net 2007.
- Garg AK, Kapoor G, Sachdeva RK. Formulation and evaluation of nizatidine floating tablets. American Journal of pharmatech Research, 2012;2(5):504-515.
- Singh B and Kim KH. Floating drug delivery system: an approach to oral controlled drug delivery system via gastric retention. Journal of Controlled Release, 2000;63:235-259.
- Waterman KC. A critical review of gastric retentive controlled drug delivery. Pharmaceutical Development and Technology, 2007;12: 1-10.
- Kotreka U and Adeyeye MC. Gastroretentive floating drug delivery system a review. Therapeutic Drug Carrier System, 2011; 28(1):47-99.
- Mayavanshi AV and Gajjar SS. Floating drug delivery system to increase gastric retention of drugs. RJPT, 2008;1(4):345-348.
- Jamil F, Sunil K, Sharma S, Vishvakarma P, Singh L. Review on stomach specific drug delivery: development and evaluation. IJRPBS, 2011;2(4):1427-1433.
- Talukder R, Fassihi R. Gastroretentive delivery systems. Drug development and industrial pharmacy,2004;30(10):1019-1028.
- Krogel I and Bodmeier R. floating or pulsatile drug delivery system based on coated effervescent cores. International Journal of Pharmaceutics, 1999;187:175-184.
- Groning R, Heun C. Oral dosage forms with controlled gastrointestinal transit drug delivery, 1984;10(4):527-539.
- 25. Agyilirah GA, Green M, Ducret R. Evaluation of gastric retention properties of cross linked polymer- coated tablet versus those of non disintegrating tablets. Int J Pharma. 1991; 75:241-247
- Despande AA, Shah NH, Rhodes CT, Malick W. Development of a novel controlled release system for gastric retention. Pharmaceutical Research,1997;14(6):815-819
- Nayak AK, Magi R, Das B. Gastroretentive drug delivery system a review. Asian Journal of Pharm Clan Res.2010;3(1):2-10.
- Santander Kaka, Deepak Bart, Raman deep Singh, Ujjwal Nautiyal. Magnetic microspheres as magical novel drug delivery system: A review. Journal of Acute Disease 2013:1-12
- Girish S, Sonar, Devendra K, Jain, Dhananjay M. Preparation and invitro evaluation of bilayer floating bioadhesive tablets of Rosiglitazone Maleate. Asian Journal of Pharmaceutical Sciences.2007;2(4):161-169.
- Sruthy PN and Anoop KR. Formulation and evaluation of olmesartan medoxomil floating tablets. International Journal of Pharmacy and Pharmaceutical Sciences, 2013;5(3):691-696.
- Pawar HA, Gharat PR, Dhavale RV, Joshi PR, Rakshit PP, Development and evaluation of gastroretentive floating tablets of an antihypertensive drug using hydrogenated cottonseed oil. ISRN, 2013;10(11):1-9.
- Khan AZ, Tripathi R, Mishra B. Floating elementary osmotic pump tablet for controlled d delivery of diethylcarbamazine citrate: a watersoluble drug. AAPS Pharm Sci Tech, 2011;12(4):1312-1323.
- Subhramananyam CVS, Setty JT. Laboratory manual of physical pharmaceutics. Vallabh prakashan 2002;pg no 212.
- Tanwar YS, Naruka PS, Ojha GR. Development and evaluation of floating microspheresof verapamil HCL. BJPS,2007;43(4):529- 534.
- Kharkhile VG, Karmarkar RR, Sontakke MA, Badgujar SD, Nemade LS. Formulation and evaluation of floating tablets of furosemide. International Journal of Pharma. Research and Development, 2012;(12):1-9.
- Chinthala SK, Kota SR, Hadassah M, Metilda, Sridevi S. Formulation and evaluation of gastroretentive floating tablets of gabapentin using effervescent technology. Int J Pharm Biomed Res, 2012;3(4):202-208.
- Arrora S, Ali J, Khar RK, Baboota S. Floatng drug delivery systems: A review. AAPS Pharm Sci Tech 2005; 6(3): 372-90.
- Vyas SP, Khar RK. Gastroretentive systems. In: Controlled drug Delivery. Vallabh Prakashan, Delhi, India. 2006. p. 197-217
- Chawla G, Gupta P, Bansal AK. Gastroretentive drug delivery systems. In: Jain NK. editor. Progress in controlled and novel drug delivery systems. CBS Publishers and Distributors. New Delhi. 2004. p. 76-97.
- Lin YH, Chang CH, Wu YS, et al. Development of pH–responsive chitosan/heparin nanoparticles for stomach–specific anti– Helicobacter pylori therapy. Biomaterials. 2009;30 (19):3332– 3342.
- GO MF. Review article: natural history and epidemiology of Helicobacter pylori infection. Aliment Pharmacol Ther. 2002; 16:3–15.
- Jain P, Jain S, Prasad KN, et al. Polyelectrolyte coated multilayered liposomes (nanocapsules) for the treatment of Helicobacter pylori infection. Mol Pharm. 2009;6(2):593–603.
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