A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Ahmad, Wajid
- Effect of Ultraviolet Radiation on various Bacterial Species
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 1 - 4Abstract
The study of microorganism is called microbiology, which includes bacteria, viruses, fungi and Protozoa. Microbes play a major role in this field. Microbes are also used for life-saving drugs etc. The effect of ultraviolet rays on the bacteria’s are mostly lethal to them, UV is a minor fraction of the solar spectrum reaching the ground surfaces, the UV light radiation will reduce the microbes in the surroundings as well as in the labs. The aim of this study was to evaluate the effect of the ultraviolet rays on pathogenic bacteria’s. Three organisms were selected for the study. Staphylococcus aureus and Streptococcus faecalis. 30 watts UV tube was used to evaluate the antibacterial activity of the UV radiation. The exposure time was determined as 5, 10 and 15 mins at a close distance of 10cm. 20 microliter of suspension was taken and mixed in 2 ml of sterile normal saline and exposed for respective duration. Sub culture was done on suitable media after the exposure. Time exposed plates were incubated at 37 degree Celsius overnight and checked for the total CFU and data were tabulated. The Ultra violet radiation of pathogenic bacteria resulted in a significant total colony forming unit. Ultraviolet rays were lethal to the bacteria’s. There are many airborne bacteria’s surrounded by environment ultraviolet rays exposure will cause an apparent decrease in the pathogenic bacteria’s.
Keywords
Bacteria, Effect, Eco friendly, Pathogenic and Ultraviolet, Innovative technology, Innovative techniqueReferences
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- Development and Characterization of Hydrogel Containing Finasteride
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 281 - 286Abstract
The major goal of this study was to create a controlled-release dosage form utilizing a cellulose-based hydrogel that was cross-linked with propylene glycol. Hydrogels were made by crosslinking the polymer Sodium Alginate + Na CMC with propylene glycol, a suitable crosslinking agent. There is no indication of interaction between the medication, polymers, and other excipients, according to an IR and DSC analysis. The hydrogel gave good swelling and controlled release properties due to the cross linking process. The effect of Calcium Chloride concentration on drug content and t75 percent CDR was found to be non-significant based on the findings. However, the influence of Calcium Chloride concentration on swelling index was substantial, indicating that as Calcium Chloride concentration rose, the swelling index of the hydrogel decreased. Again, the effect of response time on drug content and t75 of percent CDR was substantial, implying that as reaction time rose, drug content and t75 of percent CDR of hydrogel increased as well. However, the effect of response time on the swelling index was not statistically significant. Drug content, swelling index, and t75 of percent CDR of run BB1 are the best than compared with based on all responses. This run's drug content, swelling index, and t75 percent CDR are respectively 99.5 percent, 276.64 percent, and 3.5 hrs. So BB1 was used to test the improved formulation, which produced the best in vitro release of 94.24 percent in 6hrs. Different kinetic models were fitted to the in vitro data which showed the best model was higuchi with non-fickian mode of drug release and stability data showed that the formulations were stable during the time span of the study. From the study it was concluded that the prepared hydrogel can provide a sustained release effect with better bioavailability which will surely enhance its absorption throughout the body.
Keywords
Finasteride, Hydrogel, Factorial Design, Cross-linking, Controlled-Release Dosage FormReferences
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- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
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- Sharma PK, Asthana GS, Asthana A. Formulation development and evaluation of hydrogel based gastroretentive drug delivery system of antihypertensive drug. Int. J. Pharm. Clin. Res. 2016;8(10):1396-401.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1;55(3):S672-80.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co- Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Shoichet MS, Li RH, White ML, Winn SR. Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose. Biotechnology and bioengineering. 1996 May 20;50(4):374-81.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian journal of pharmaceutical education and research. 2021 Jan 1;55(1):86-94.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- Formulation and Evaluation of Yohimbine HCl Proliposomal Gels
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 302 - 306Abstract
The study was aimed to develop a proliposomal formulation for anti- inflammatory drug Yohimbine HCl. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin- film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in the gel (carbopol) and characterized for their rheology and in vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The In-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.
Keywords
Proliposomes, Yohimbine HCl, film hydration, anti-inflammatory and Rheological studiesReferences
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- Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced Drug Delivery Reviews. 2010 Jan 31;62(1):83-99.
- Ishihara M, Obara K, Nakamura S, Fujita M, Masuoka K, Kanatani Y, Takase B, Hattori H, Morimoto Y, Ishihara M, Maehara T. Chitosan hydrogel as a drug delivery carrier to control angiogenesis. Journal of Artificial Organs. 2006 Mar;9(1):8-16.
- Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-5.
- Obaid FN, Jaffat HS. Physiological and histological study of the effect of finasteride drug (Prostacare) on the fertility of albino male rats. Research Journal of Pharmacy and Technology. 2018;11(6):2323-5.
- Park SY, Kim KB, Ahn SH, Kim HH. The effects of SM-215 on androgeneticalopecia. Research Journal of Pharmacy and Technology. 2018;11(5):1745-51.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Nandhakumar L, Dharmamoorthy G, Chandrasekaran S. Hydrogels: A multifaceted contemporary approaches and advancements. Research Journal of Pharmacy and Technology. 2011;4(11):1658-62.
- Deepthi B, Varun D, Gopal PN, Rao CH, Sumalatha G. Super porous hydrogels–Supreme drug delivery. Research Journal of Pharmacy and Technology. 2011;4(8):1182-8.
- Saranya R, Elango K, Devi DN, Balaguru A. Formulation and Evaluation of Hydrogel for Stomach Specific Drug Delivery of Lamivudine. Research Journal of Pharmacy and Technology. 2013;6(7):740-5.
- Kundu T, Mukherjee K, Biswanath S. Hydrogel beads composed of sodium carboxymethyl xanthan and sodium carboxymethyl cellulose for controlled release of aceclofenac: effect of formulation variables. Research Journal of Pharmacy and Technology. 2012;5(1):103-13.
- Saleem MA, Kulkarni RV, Patil NG. Formulation and evaluation of chitosan based polyelectrolyte complex hydrogels for extended release of metoprolol tartrate. Research Journal of Pharmacy and Technology. 2011;4(12):1844-51.
- Sami AJ, Khalid M, Jamil T, Aftab S, Mangat SA, Shakoori AR, Iqbal S. Formulation of novel chitosan guargum based hydrogels for sustained drug release of paracetamol. International journal of biological macromolecules. 2018 Mar 1;108:324-32.
- Sharma PK, Asthana GS, Asthana A. Formulation development and evaluation of hydrogel based gastroretentive drug delivery system of antihypertensive drug. Int. J. Pharm. Clin. Res. 2016;8(10):1396-401.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1;55(3):S672-80.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co- Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Shoichet MS, Li RH, White ML, Winn SR. Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose. Biotechnology and Bioengineering. 1996 May 20;50(4):374-81.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- A Comprehensive Review on Targeted Drug Delivery System
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Angola, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 335 - 340Abstract
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, and cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
Keywords
Targeted Drug Delivery, Microspheres, Nanoparticles, Liposomes, Monoclonal antibodiesReferences
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