In-Silico Analysis of Targeted Drug Delivery to Hepatic Cells using Lipid Nano-Particles to Treat Liver Diseases

Liver diseases are the second most predominant diseases next to diabetes. Treatment of most of the liver diseases involves liver transplantation, which is not feasible due to lack of sufficient donors. Most of the drugs prescribed are random and doesn't involve proper action in the patient. Hence targeted delivery of the drug is the most viable and affordable solution for treating liver diseases. Despite many available carriers like viral vectors, metallic vectors etc, liposomes are the most suitable drug carrier molecules and they are more advantageous than other materials. Targeted delivery experiments involve much tedious experimental procedures and complex biological pathway study. Developing and analysing these nano scale compounds are also much difficult and hence for the ease of work, tools of Bioinformatics are used to analyse and interpret the results. Hence in-Silico analysis are commonly used for analysing their pathway before carrying out the in-Vitro and in-Vivo experiments. This review article emphasis on the various procedures and software used in targeted delivery experiments.