Folate Mediated Drug Delivery using Nanoparticle

Many drugs are in the treatment of cancer, doxorubicin (DOX), a common cancer chemotherapeutics, was conjugated to folate-modified polyethyleneimine-functionalized gold nanoparticles. The controlled release behaviour of DOX-loaded gold nanoparticles was analysed using Tris HCl and PBS. The TEM and FTIR characterization says that there isa strong association of DOX over folate modified gold nanoparticle. DOX-loaded gold nanoparticles had higher cytotoxicity for folate-receptor-positive cells (KB cells) compared to folate-receptor-negative cells (A549 cells) which show lower cells viability at higher concentration of folate modified gold nanoparticle. The viability of KB cells is 7% and A549 cells are 17% at high concentration AuNP-PEI-FOL-DOX. The DOX effects on cancer cell DNA were determined by DNA cleavage pattern.