Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Development of a Compression Coated, Matrix Based, Tablet of Verapamil HCl using Design of Experiments


Affiliations
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, India
2 Department of Pharmaceutics, J S S College of Pharmacy, Ooty-643001, A.P, India
     

   Subscribe/Renew Journal


Compression coating provides a unique platform for formulating modified release products in a way the dosage form can successfully be targeted to localize the release of the drug in any desired portion of the GIT without the additional step of film coating. The current work focuses on the development and optimization of modified release Verapamil Hydrochloride tablets using compression coating. The effect of various concentrations of different grades HPMC polymers, like, K4M, K15M and K100M on the release profile was studied in DOE environment. The results of the DOE provide an optimized range of the three polymers which could potentially give the targeted release profile for all drugs which have solubility profiles similar to Verapamil HCl. Three batches of optimized formulation were loaded on to accelerated stability studies at 40° C/75% RH in HDPE containers and the 3 months stability data indicates that there is no significant change in either the potency of the dosage form or its in vitro dissolution profile.

Keywords

Verapamil, DOE, HPMC, Formulation.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Yeswanth Reddy Musukula: Design and Evaluation of Compression Coated Colon Targeted Tablets of Ketorolac Tromethamine by Using Natural Polymers and Their Combination with Hpmc K100m.Int. J Rese in Pharm Nano Sci.2014;3:408-417.

  • Patel Rushikesh Chandubhai, Sindhu Abraham, Srinivasan Bharath, Varadharajan Madhavan: Compression coated tablets of Flurbiprofen- A chronotherapeutic approach. J Sci. Innov Res.2013;2:914-926.

  • Ray Brijesh, M.M. Gupta: Formulation and Evaluation of Once Daily Sustained Release Matrix Tablet of Verapamil Hydrochloride. J Drug Deli Thera.2013;3:55-58

  • Margret Chandira, Mehul, Debjit, Chiranjib, Kumudhavalli, B. Jayakar formulation, Design and Development of Buccoadheshive Tablets of Verapamil Hydrochloride. Int. J Pharm Res.2009;1:1663-1677.

  • Birajdar Shivprasad M., Bhusnure Omprakash G, Mulaje Suraj S: Formulation and Evaluation of Fast Disintegrating Losartan Potassium Tablets by Formal Experimental Design. Int J Res Deve Pharma Life Sci.2014; 3:1136-1150.

  • Nandini. D. Banerjee, Sushma R: Formulation and Evaluation of Compression Coated Tablets of Cefpodoxime Proxetil. Inter J Pharma Sci. Rese.2013;7:104-112.

  • SS. Khadabadi, Nahid H. Chishti, Farhan M. Khan, Akeel A. Tadvee: Formulation and Evaluation of Press Coated Tablet of Ketoprofen – A Chronotherapeutic Approach. Inter J Pharm Pharmac Sci.2013;5:733-740.

  • Parag A. Kulkarni, Mahendra Jaiswal, Santosh B. Jawale, Satish V. Shirolkar, Pramod V. Kasture: Development and Evaluation of Press Coated Tablets for Chronopharmaceutical Drug Delivery Using Gellable and Permeable Polymers. Scho Res Lib. 2010;2:482-497.


Abstract Views: 257

PDF Views: 0




  • Formulation and Development of a Compression Coated, Matrix Based, Tablet of Verapamil HCl using Design of Experiments

Abstract Views: 257  |  PDF Views: 0

Authors

Subhashis Debnath
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, India
C. Shashank
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, India
M. Niranjan Babu
Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, India
R. Suresh Kumar
Department of Pharmaceutics, J S S College of Pharmacy, Ooty-643001, A.P, India

Abstract


Compression coating provides a unique platform for formulating modified release products in a way the dosage form can successfully be targeted to localize the release of the drug in any desired portion of the GIT without the additional step of film coating. The current work focuses on the development and optimization of modified release Verapamil Hydrochloride tablets using compression coating. The effect of various concentrations of different grades HPMC polymers, like, K4M, K15M and K100M on the release profile was studied in DOE environment. The results of the DOE provide an optimized range of the three polymers which could potentially give the targeted release profile for all drugs which have solubility profiles similar to Verapamil HCl. Three batches of optimized formulation were loaded on to accelerated stability studies at 40° C/75% RH in HDPE containers and the 3 months stability data indicates that there is no significant change in either the potency of the dosage form or its in vitro dissolution profile.

Keywords


Verapamil, DOE, HPMC, Formulation.

References