Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Evaluation of Mouth Dissolving Tablets of Carbamazepine


Affiliations
1 Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, India
     

   Subscribe/Renew Journal


Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouth-dissolving tablets of Carbamazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared using two different technologies, direct compression method and solid dispersion technology. Tablets produced by direct compression method contain crospovidone as a super disintegrant and sorbitol as a sweetener. Solid dispersions of Carbamazepine with polyvinylpyrrolidone K-30 and polyethylene glycol 6000 in different weight ratios were prepared with a view to increase its water solubility. Carbamazepine solid dispersions with polyvinylpyrrolidone K-30 in 1:2 ratios of drug: carrier showed maximum drug release and hence, compressed along with other excipients into mouth dissolving tablet. The results compared for both the technologies showed that the Carbamazepine tablets prepared using solid dispersion technology was found to have good technological properties and satisfying and reproducible drug dissolution profiles. Moreover, the drug release was found to be comparable to the marketed dispersible tablet.

Keywords

Carbamazepine, Mouth Dissolving Tablets, PVP K30, PEG 6000, Solid Dispersions, FT-IR, Dissolution Rate.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Seager H. Drug-delivery Products and the Zydis Fast-dissolving Dosage Form. J Pharm Pharmacol 1998; 50:375-382.

  • Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. Fast Dissolving Drug Delivery Systems. JAMA India 2001; 4(10): 27-31.

  • Bang L, Goa K. Carbamazepine: a review of its use in children with epilepsy. Paediatr Drugs 2003; 5(8): 557-73.

  • Wellington K, Goa KL. Carbamazepine: an update of its efficacy in the management of epilepsy. CNS Drugs 2001; 15(2): 137-63.

  • Toshifusa S, Hideshi S, Kenji H, Kunio I. Studies of rapidly disintegrating tablets in oral cavity using co ground mixtures of mannitol with crospovidone. Chem Pharm Bull 2002; 50(2): 193198.

  • Franco M, Trapani G, Latrofa A et al. Dissolution properties and anticonvulsant activity of phenytoin-PEG 6000 and PVP K30 solid dispersion. Int J Pharm 2001; 225:63-73.

  • Ahmad M Abdul-Fattah, Bhargva HN. Preparation and in vitro evaluation of solid dispersion of halofantrine. Int J Pharm 2002; 235:17-33.

  • Van den Mooter G, Augustijns P, Blaton N, Kinget R. Physicochemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. Int J Pharm 1998; 164:67-80.

  • Ryh-Nan P, Jing-Huey C, Rhei-Long C. Enhancement of dissolution and bioavailability of piroxicam in solid dispersion system. Drug Dev Ind Pharm 2000; 26(9): 989-994.

  • Dobetti L. Fast melting tablets: Development and technology. Pharm Tech Drug Delivery 2001; 44-50.

  • Bi Y, Sunada H, Yonezawa Y, Danjo K, Iida K. Preparation and evaluation of compressed tablets rapidly disintegrating in the oral cavity. Chem Pharm Bull (Tokyo) 1996; 44: 2121-2127.

  • Andries F. Marais, Mingna Song, Melgardt M. de Villiers. Effect of compression force, humidity and disintegrant concentration on the disintegration and dissolution of directly compressed furosemide tablets using croscarmellose sodium as disintegrant. Tropl J Pharm Res 2003; 2:125-135.

  • Shenoy V, Agrawal S, Pandey S. Optimizing fast dissolving Dosage form of Diclofenac Sodium by rapidly disintegrating agents. Indian J Pharm Sci 2003; 65(2): 197-201.

  • Debord B, Lefebvre C, Guyot Hermann AM, Bouche R, Guyot JC. Study of different crystalline forms of mannitol comparative behavior under compression. Drug Dev Ind Pharm 1987; 13:1533-1546.

  • Pharmapedia.http://www.pharmpedia.com/Tablet:Formulation_of_tablets/Diluents.

  • Patel DM, Patel NM, Shah RR, Jogani PD, Balapatel AI. Studies in formulation of orodispersible tablets of rofecoxib. Ind J Pharm Sci 2004; 66(5): 621-625.

  • Najib NM, Suleiman M, Malakh A. Characteristics of the in vitro release of ibuprofen from polyvinylpyrrolidone solid dispersions. Int J Pharm 1986; 32:229-236.

  • Corrigan OI, Murphy CA, Timoney RF. Dissolution properties of polyethylene glycols and polyethylene glycol-drug systems. Int J Pharm 1979; 4:67-74.

  • Dubois JL, Ford JL. Similarities in the release rates of different drugs from polyethylene glycol 6000 dispersions. J Pharm Pharmacol 1985; 37:494-495.

  • Craig DQM, Newton JM. The dissolution of nortriptyline hydrochloride from polyethylene glycol solid dispersions. Int J Pharm 1992; 78:175-182.

  • Saers Sjokvist E, Craig DQM. An investigation into the mechanisms of dissolution of alkyl p-aminobenzoates from polyethylene glycol solid dispersions. Int J Pharm 1992; 83:211219


Abstract Views: 260

PDF Views: 0




  • Formulation and Evaluation of Mouth Dissolving Tablets of Carbamazepine

Abstract Views: 260  |  PDF Views: 0

Authors

V. Jhansipriya Marabathuni
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
M. Bhavani
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
M. Lavanya
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
K. Padmaja
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
N. Madhavi
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
P. Babu
Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, India
Ch. M. M. Prasada Rao
Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, India

Abstract


Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouth-dissolving tablets of Carbamazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared using two different technologies, direct compression method and solid dispersion technology. Tablets produced by direct compression method contain crospovidone as a super disintegrant and sorbitol as a sweetener. Solid dispersions of Carbamazepine with polyvinylpyrrolidone K-30 and polyethylene glycol 6000 in different weight ratios were prepared with a view to increase its water solubility. Carbamazepine solid dispersions with polyvinylpyrrolidone K-30 in 1:2 ratios of drug: carrier showed maximum drug release and hence, compressed along with other excipients into mouth dissolving tablet. The results compared for both the technologies showed that the Carbamazepine tablets prepared using solid dispersion technology was found to have good technological properties and satisfying and reproducible drug dissolution profiles. Moreover, the drug release was found to be comparable to the marketed dispersible tablet.

Keywords


Carbamazepine, Mouth Dissolving Tablets, PVP K30, PEG 6000, Solid Dispersions, FT-IR, Dissolution Rate.

References