Asian Journal of Pharmacy and Technology

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Antidiabetic Efficacy of Methanol Extract Brown Alga Lobophora variegata on Alloxan Stimulated Hyperglycemic Wistar Albino Rats


Affiliations
1 Division of Algal Biotechnology and Bionano Technology, Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, India
2 Research Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, India
     

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To investigate the effect of methanol extract of Lobophora variegata for its antihyperglycemic activity against alloxan induced diabetic rats. The methanol residue of Lobophora variegata was given orally at a dosage of 10 mg/kg weight to diabetic animals for about 28 days. The outcome of algae residue feeding was estimated by various biochemical and haematological parameters such as RBC, WBC, HB and platelets and lipid profile. Histopathological evaluation was made in the pancreas. After feeding of methanol extract in diabetic rats for 28 days, the blood glucose has significantly decreased, while the increase in liver glycogen level was observed. In addition, the regeneration of the pancreas of the treated animals was also noticed. The methanol residues of the Lobophora variegata possess very effective anti-hyperglycemic activity on the diabetic rats as compared to Glipizide.

Keywords

Lobophora variegata, Alloxan Monohydrate, Carbohydrate Metabolism, Diabetes Mellitus, Brown Algae.
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  • Antidiabetic Efficacy of Methanol Extract Brown Alga Lobophora variegata on Alloxan Stimulated Hyperglycemic Wistar Albino Rats

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Authors

Sathyaseelan Thennarasan
Division of Algal Biotechnology and Bionano Technology, Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, India
Subbiah Murugesan
Division of Algal Biotechnology and Bionano Technology, Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, India
Vajiravelu Sivamurugan
Research Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, India

Abstract


To investigate the effect of methanol extract of Lobophora variegata for its antihyperglycemic activity against alloxan induced diabetic rats. The methanol residue of Lobophora variegata was given orally at a dosage of 10 mg/kg weight to diabetic animals for about 28 days. The outcome of algae residue feeding was estimated by various biochemical and haematological parameters such as RBC, WBC, HB and platelets and lipid profile. Histopathological evaluation was made in the pancreas. After feeding of methanol extract in diabetic rats for 28 days, the blood glucose has significantly decreased, while the increase in liver glycogen level was observed. In addition, the regeneration of the pancreas of the treated animals was also noticed. The methanol residues of the Lobophora variegata possess very effective anti-hyperglycemic activity on the diabetic rats as compared to Glipizide.

Keywords


Lobophora variegata, Alloxan Monohydrate, Carbohydrate Metabolism, Diabetes Mellitus, Brown Algae.

References