Asian Journal of Pharmacy and Technology

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Formulation, Optimization and Evaluation of Drotaverine HCl Mini Tablet


Affiliations
1 Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India
     

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The aim of present research was to develop a mini tablet of Drotaverine hydrocholoride. Mini tablets of Drotaverine hcl were prepared by using various polymers, such as gellan gum and carbopol 940. Mini tablets were evaluated for weight variation, hardness, thickness, friability, drug content, and in-vitro dissolution studies. The prepared mini tablets exhibited satisfactory physic-chemical characteristics. All prepared batches shown good in-vitro dissolution studies. The best result from optimized batches is of F5 which gives drug release 97.72% in 12 h time periods.

Keywords

Drotaverine Hcl, Mini Tablet, Optimization, Gellan Gum, Direct Compression
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  • Formulation, Optimization and Evaluation of Drotaverine HCl Mini Tablet

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Authors

Mohd Salman
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India
A. Qazi Majaz
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India
Abrarul Haq
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India
Khan Nayeem
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India
Shaikh Siraj
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Dist.: Nandurbar (425415), Maharashtra, India

Abstract


The aim of present research was to develop a mini tablet of Drotaverine hydrocholoride. Mini tablets of Drotaverine hcl were prepared by using various polymers, such as gellan gum and carbopol 940. Mini tablets were evaluated for weight variation, hardness, thickness, friability, drug content, and in-vitro dissolution studies. The prepared mini tablets exhibited satisfactory physic-chemical characteristics. All prepared batches shown good in-vitro dissolution studies. The best result from optimized batches is of F5 which gives drug release 97.72% in 12 h time periods.

Keywords


Drotaverine Hcl, Mini Tablet, Optimization, Gellan Gum, Direct Compression

References