Asian Journal of Pharmacy and Technology

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Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone


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1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, India
     

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The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).

Keywords

Risperidone, Mucoadhesive Buccal Tablets, Carbopol, Karaya Gum, and Sodium Carboxy Methyl Cellulose
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  • Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone

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Authors

Dasari Nirmala
Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, India
Vaddi Harika
Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, India
Muvvala Sudhakar
Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, India

Abstract


The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).

Keywords


Risperidone, Mucoadhesive Buccal Tablets, Carbopol, Karaya Gum, and Sodium Carboxy Methyl Cellulose

References