Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Fabrication and Evaluation of Cefpodoxime Proxetil Niosomes


Affiliations
1 Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu, Andhra Pradesh, India
     

   Subscribe/Renew Journal


The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.

Keywords

Niosomes, Spans, Cefpodoxime Proxetil, Cholesterol, Injection, Evaluation
Subscription Login to verify subscription
User
Notifications
Font Size


  • Lohumi A. A novel drug delivery system: niosomes review. Journal of Drug Delivery and Therapeutics. 2012 Sep 15;2(5).

  • Todd WM. Cefpodoxime proxetil: a comprehensive review. International Journal of Antimicrobial Agents. 1994 Mar 1;4(1):37-62.

  • Moghassemi S, Hadjizadeh A. Nano-niosomes as nanoscale drug delivery systems: an illustrated review. Journal of Controlled Release. 2014; 185: 22-36.

  • Ahad HA, Rani EM, Kranthi G, Gupta PR, Reddy MN, Prakash G. Spectrophotometric Determination of Cefadroxil in Cefadroxil Tablets by Bromination Method. Analytical Chemistry Letters. 2011; 1(2): 185-8.

  • Ahad HA, Sreenivasulu R, Mallapu Rani E, Reddy BV. Preparation and evaluation of famotidine high density gastro retentive microspheres with synthetic and natural polymers. Journal of Pharmaceutical Education and Research. 2011; 2(1).

  • Annepogu H, Hindustan Abdul AH, Nayakanti D. Determining the best poloxamer carrier for thiocolchicoside solid dispersions. Turkish Journal of Pharmaceutical Sciences. 2020; 17(4): 372.

  • Muzzalupo R, Tavano L, Cassano R, Trombino S, Ferrarelli T, Picci N. A new approach for the evaluation of niosomes as effective transdermal drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics. 2011; 79(1): 28-35.

  • Harsha SS, Ahad HA, Haranath C, Dasari RR, Gowthami M, Varam NJ, Musa GB. Exfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheres. Journal of Evolution of Medical and Dental Sciences. 2020; 9(14): 1156-61.

  • Hindustan AA, Sreenivasulu R, Mallapu Rani E, Reddy BV. Preparation and evaluation of famotidine high density gastro retentive microspheres with synthetic and natural polymers. Journal of Pharmaceutical Education and Research. 2011; 2(1).

  • Sakthivel M, Kannan K, Manavalan R, Senthamarai R. Formulation and in vivo Evaluation of Niosomes containing Oxcarabazepine. Journal of Pharmaceutical Sciences and Research. 2013; 5(1): 8.

  • Sankhyan A, Pawar P. Recent trends in niosome as vesicular drug delivery system. Journal of Applied Pharmaceutical Science. 2012; 2(6): 20-32.

  • Indian Pharmacopoeia, New Delhi, India: Ministry of Health and Family Welfare; 2010. Indian Pharmacopoeia, Controller of Publication, Govt. of India; p. 185.

  • Sailaja AK. Niosomes–A Novel Drug Carries for Drug Targeting. Mintage Journal of Pahrmaceutical and Medical Sciences. 2016; 5(1): 8-15.


Abstract Views: 123

PDF Views: 0




  • Fabrication and Evaluation of Cefpodoxime Proxetil Niosomes

Abstract Views: 123  |  PDF Views: 0

Authors

Bandagisa Fouziya
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Hindustan Abdul Ahad
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu, Andhra Pradesh, India
Dontha Swamy Charan
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Jagarlamudi Sri Vidya
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Ummadi Chandana Reddy
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India
Puli Nandini Reddy
Nirmala College of Pharmacy, Chennai - Hyderabad Bypass Road, Ukkayapalli, Kadapa - 516002, AP, India

Abstract


The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.

Keywords


Niosomes, Spans, Cefpodoxime Proxetil, Cholesterol, Injection, Evaluation

References