Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hydrotropy: A Promising Tool for Solubility Enhancement


Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
     

   Subscribe/Renew Journal


Solubility is one of the key parameters to attain desired concentration of drug in systemic circulation to show pharmacological response. Various methods are engaged to augment the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. Based on advantages like the high selectivity, independent of pH and cheap, easy availability makes this technique more prevailing than other solubilisation methods. Mixed hydrotropy is a solubilisation technique to augment the water solubility of poorly water soluble drugs by the way of different ratio of blends of hydrotropic agents which gives synergistic augmentation effect. The purpose of this review article is to illustrate the need for solubility, hydrotropic solubilisation, mechanism of action of hydrotrope, classification of hydrotropes, advantages and mixed hydrotropic technique of solubilisation for improving the solubility which in turn helps to attain absorption and improved bioavailability.

Keywords

Hydrotropy, Hydrotropes, Solubility, Mixed Hydrotropy, Solubilisation
Subscription Login to verify subscription
User
Notifications
Font Size


  • Kapadiya Nidhi, Singhvi Indrajeet, Mehta Khushboo, Karwani Gauri, Dhrubo Jyoti Sen. Hydrotropy: A promising tool for solubility enhancement: A Review. International Journal of Drug Development & Research 2011; 3(2): 26 – 33.

  • V. Sampath Kumar, C. Raja, C. Jayakumar. A review on solubility enhancement using hydrotropic phenomena. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 6(6): 1 – 7.

  • R. K. Maheshwari and Y. Jagwani. Mixed Hydrotropy: Novel Science of solubility Enhancement. Indian Journal of Pharmaceutical Sciences 2011; 73(2): 179 – 183.

  • Md. Ali Sajid, Vicky Choudhary. Solubility Enhancement Methods with importance of hydrotropy. Journal of Drug Delivery and Therapeutics 2012; 2(6): 96 – 101.

  • Vividha Dhapte, Piyush Mehta. Advances in hydrotropic solutions: An updated review. St. Petersburg Polytechnical University Journal: Physics and Mathematics 2015; 1: 424 – 435.

  • Varun Raj Vemula, Venkateshwarlu Lagishetty, Srikanth Lingala. Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research 2010; 5(1): 41 – 51.

  • Satish Polshettiwar, Snehal Shivaji Khorate. Mixed Hydrotropy: A rising tool for solubility enhancement of transdermal drug delivery and cosmeceutical applications. Indo American Journal of Pharmaceutical Research 2016; 6 (10): 6680 – 6690.

  • K. Girishpai, S. Divya, M. Reddy, L. Kumar, V. Krishna. Solubility enhancement of norfloxacin by hydrotropy technique. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 6 (8): 395 – 397.

  • C. Jayakumar, A. Morais, N. Arunodhaya, N. Gandhi. Solubility enhancement of theophylline drug using different solubilisation techniques. International Journal of Pharmaceutical and Clinical Science 2012; 2(1): 7 – 10.

  • Mangesh R. Patil, Saurabh B. Ganorkar, Amod S. Patil, Atul A. Shirkhedkar and Sanjay J. Surana. Hydrotropic Solubilization in Pharmaceutical Analysis: Origin, Evolution, Cumulative Trend and Precise Applications. Critical Reviews in Analytical Chemistry 2021; 51(3): 278 - 288.

  • Jyoti Joshi, Nidhi Nainwal Sharma, Vikas Anand Saharan. A review on hydrotropy: A potential approach for the solubility enhancement of poorly soluble drug. Asian Journal of Pharmaceutical and Clinical Research 2019; 12(10): 19 – 26.

  • Avital Beig, David Lindley, Jonathan M. Miller, Riad Agbaria1 and Arik Dahan. Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay. Frontiers in Pharmacology 2016; 7: Article 379.

  • Asmat Majeed, Syed Naiem Raza and Nisar Ahmad Khan. Hydrotrophy: Novel solubility enhancement technique: a review. International Journal of Pharmaceutical Sciences and Research 2019; 10(3): 1025-1036.

  • K. Venkata Gopaiah. Hydrotropic technique: a promising method to enhance aqueous solubility of nimesulide and to reduce difficulties in bioavailability. Asian Journal of Pharmaceutics 2018; 12(4): 2951 -2960.

  • Alka N Choudhary and Suhasini Nayal. A review: Hydrotropy a solubility enhancing technique. The Pharma Innovation Journal 2019; 8(4): 1149-1153.

  • Sneha Jagtap, Chandrakant Magdum, Dhanraj Jadge, Rajesh Jagtap. Solubility Enhancement Technique: A Review. Journal of Pharmaceutical Sciences and Research 2018; 10(9): 2205-2211.

  • Sikarra Deepshikha, Shukla Vaibhav, Kharia Ankit Anand. Review Article Techniques for Solubility Enhancement of Poorly Soluble Drugs: An Overview. Journal of Medical Pharmaceutical and Allied Sciences 2012; 01: 18-38.

  • Priyanka Arjaria. Hydrotropic Solubilization. International Journal of Pharmaceutical and Psychopharmacological Research 2013; 3(1):17-23.

  • Deepak Ghogare, Sheetal Patil. Hydrotropic Solubilization: Tool for Eco-Friendly Analysis, International Journal of Pharmacy and Pharmaceutical Research 2018; 11(3): 300-322.

  • Rajawardhan Reddy. A Review on Hydrotropy. Journal of Pharma Research. 2013; 2(4): 5-6.

  • Prakash Khadka, Jieun RO. Pharmaceutical Particle Technologies: An Approach to Improve Drug Solubility, Dissolution and Bioavailability. Asian Journal of Pharmaceutical Sciences 2014; 9: 304-316.

  • Keshav Jindal. Reviewon Solubility: A Mandatory Tool for Pharmaceuticals. International Research Journal of Pharmacy 2017; 8(11): 11-15.

  • Kadam SV, Shinkar DM, Saudagar RB. Review on Solubility Techniques. International Journal of Pharmacy and Biological Sciences 2013; 1: 462-475.

  • Badwan AA, El-Khordagui LK, Saleh AM. The Solubility of Benzodiazepines In Sodium Salicylate Solutions And A Proposed Mechanism For Hydrotropic Solubilisation. Int. J Pharm. 1983; 13: 67 - 74.

  • Avinash Dhobale V, Gunesh Dhembre N. Solubility Enhancement Techniques A Review, IAJPS 2018; 05(04): 2798-2810.

  • Sandeep Kumar, Pritam Singh. Various Techniques for Solubility Enhancement: An Overview. The Pharma Innovation Journal 2016; 5(1): 23-28.


Abstract Views: 139

PDF Views: 0




  • Hydrotropy: A Promising Tool for Solubility Enhancement

Abstract Views: 139  |  PDF Views: 0

Authors

G. Kalyani
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
P. Bhuvaneswari
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
B. Hemalatha
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
K. Padmalatha
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India

Abstract


Solubility is one of the key parameters to attain desired concentration of drug in systemic circulation to show pharmacological response. Various methods are engaged to augment the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. Based on advantages like the high selectivity, independent of pH and cheap, easy availability makes this technique more prevailing than other solubilisation methods. Mixed hydrotropy is a solubilisation technique to augment the water solubility of poorly water soluble drugs by the way of different ratio of blends of hydrotropic agents which gives synergistic augmentation effect. The purpose of this review article is to illustrate the need for solubility, hydrotropic solubilisation, mechanism of action of hydrotrope, classification of hydrotropes, advantages and mixed hydrotropic technique of solubilisation for improving the solubility which in turn helps to attain absorption and improved bioavailability.

Keywords


Hydrotropy, Hydrotropes, Solubility, Mixed Hydrotropy, Solubilisation

References