Asian Journal of Research in Chemistry

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Determination of Cetrizine Dihydrochloride and a Related Impurity in Oral Solution and Tablet Dosage Forms Using HPLC


Affiliations
1 Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur– 342003, Rajasthan, India
2 Glenmark Pharmaceuticals Ltd., Mumbai, India
     

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Cetirizine dihydrochloride (CZ) is (RS)-2-[2-[4-[(4- chlorophenyl) phenyl methyl] piperazine-1-yl] ethoxy] acetic acid dihydrochloride and is a long acting nonsedating antihistamine drug with some mast-cell stabilizing activity. CZ is therapeutically applied for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria.


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  • Determination of Cetrizine Dihydrochloride and a Related Impurity in Oral Solution and Tablet Dosage Forms Using HPLC

Abstract Views: 250  |  PDF Views: 0

Authors

Yogendra Singh
Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur– 342003, Rajasthan, India
Subhash Pande
Glenmark Pharmaceuticals Ltd., Mumbai, India
Bhupendra Singh
Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur– 342003, Rajasthan, India
Veerma Ram
Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur– 342003, Rajasthan, India
Anil Bhandari
Jodhpur National University, Narnadi, Jhanwar Road, Jodhpur– 342003, Rajasthan, India

Abstract


Cetirizine dihydrochloride (CZ) is (RS)-2-[2-[4-[(4- chlorophenyl) phenyl methyl] piperazine-1-yl] ethoxy] acetic acid dihydrochloride and is a long acting nonsedating antihistamine drug with some mast-cell stabilizing activity. CZ is therapeutically applied for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria.