Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Method

Two spectroscopic methods for simultaneous estimation of cefpodoxime proxetil (CP) and ofloxacin (OFL) in combined tablet dosage form have been developed. The first method is simultaneous equations method which involves the formation of simultaneous equations at 234.90 nm (λ_max of cefpodoxime) and 298 nm (λ_max of ofloxacin). The second method is Q-analysis method (Q-absorbance ratio), which involves the formation of Q-absorbance equation at 271.60 nm (Iso-absorptive point) and 298 nm (λ_max of ofloxacin). In this both method the linearity was evaluated over the concentration range of 2-10μg/ml for cefpodoxime and ofloxacin. The accuracy of the methods were assessed by recovery studies and was found to be 100.9±0.16% and 98.22±0.44% for simultaneous equations method and 99.5±0.133% and 98.90±0.65% for Q-absorbance ratio method for cefpodoxime and ofloxacin respectively. The proposed methods are simple, accurate, precise, rapid and cost effective. Therefore the proposed methods can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.