Asian Journal of Research in Chemistry

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Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice


Affiliations
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), India
2 Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India
     

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The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.


Keywords

Celastrus paniculatus Willd, Phytochemical Convulsion, Maximal Electroshock, Mice.
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  • Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice

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Authors

Vijay Yadav
Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), India
Vimal Yadav
Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), India
S. K. Jain
Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India
V. K. Singh
Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India
S. K. Prajapati
Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India

Abstract


The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.


Keywords


Celastrus paniculatus Willd, Phytochemical Convulsion, Maximal Electroshock, Mice.