Asian Journal of Research in Chemistry

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Simultaneous Estimation of Atorvastatin Calcium and Felodipine by UV-Spectrophotometric Method in Formulation


Affiliations
1 Sree Vidyanikethan College of Pharmacy, A.Rangampeta, Tirupati-517102, AP, India
2 SCBT, SASTRA University, Dept. of Pharmacy, Pharmaceutical Analysis, Thanjavur-613401, Tamilnadu, India
     

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A simple, accurate, precise, sensitive and a highly selective UV spectrophotometric method was developed for the simultaneous estimation of Atorvastatin calcium and Felodipine. The Estimation of Atorvastatin calcium was carried out at wavelength 241nm, while Felodipine was estimated as single component at 366.5nm. The method was found to be linear in the range of 2-10μg/ml for each Atorvastatin calcium and Felodipine. The developed method was validated according to ICH guidelines and it found to be accurate and precise. Thus the proposed method can be successfully applied for simultaneous determination of Atorvastatin calcium and Felodipine in routine analysis work.

Keywords

Atorvastatin Calcium, Felodipine, UV Spectrophotometric Method.
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  • Simultaneous Estimation of Atorvastatin Calcium and Felodipine by UV-Spectrophotometric Method in Formulation

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Authors

K. Rajesh
Sree Vidyanikethan College of Pharmacy, A.Rangampeta, Tirupati-517102, AP, India
R. Rajalakshmi
Sree Vidyanikethan College of Pharmacy, A.Rangampeta, Tirupati-517102, AP, India
S. Vijayaraj
Sree Vidyanikethan College of Pharmacy, A.Rangampeta, Tirupati-517102, AP, India
T. Sreelakshmi
SCBT, SASTRA University, Dept. of Pharmacy, Pharmaceutical Analysis, Thanjavur-613401, Tamilnadu, India

Abstract


A simple, accurate, precise, sensitive and a highly selective UV spectrophotometric method was developed for the simultaneous estimation of Atorvastatin calcium and Felodipine. The Estimation of Atorvastatin calcium was carried out at wavelength 241nm, while Felodipine was estimated as single component at 366.5nm. The method was found to be linear in the range of 2-10μg/ml for each Atorvastatin calcium and Felodipine. The developed method was validated according to ICH guidelines and it found to be accurate and precise. Thus the proposed method can be successfully applied for simultaneous determination of Atorvastatin calcium and Felodipine in routine analysis work.

Keywords


Atorvastatin Calcium, Felodipine, UV Spectrophotometric Method.