Asian Journal of Research in Chemistry

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Absorption Correction Method for Simultaneous Estimation of Tizanidine and Aceclofenac in Bulk Drug and Tablet Formulation


Affiliations
1 Department of Pharmaceutical Chemistry, STES’S, Smt. Kashibai Navale College of Pharmacy, Kodhwa, Pune - 411048, India
     

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The present study deals with UV spectrophotometric method development and Validation for estimation of Tizanidine and Aceclofenac in bulk drug and tablet dosage form by absorption correction by interference method. The method is based on by using two wavelengths, 274 nm for aceclofenac and 318 nm for Tizanidine. The Linearity of Tizanidine and Aceclofenac was found to be in the range 0f 2-10 μg/ml and 5-25 μg/ml respectively. The % recovery of Tizanidine and Aceclofenac was found out to be 98-102 % respectively. The proposed method was validated as per ICH guidelines.

Keywords

Aceclofenac, Tizanidine, Absorption Correction Method.
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  • Absorption Correction Method for Simultaneous Estimation of Tizanidine and Aceclofenac in Bulk Drug and Tablet Formulation

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Authors

Sujata J. Gondane
Department of Pharmaceutical Chemistry, STES’S, Smt. Kashibai Navale College of Pharmacy, Kodhwa, Pune - 411048, India
M. P. Mahajan
Department of Pharmaceutical Chemistry, STES’S, Smt. Kashibai Navale College of Pharmacy, Kodhwa, Pune - 411048, India
S. D. Sawant
Department of Pharmaceutical Chemistry, STES’S, Smt. Kashibai Navale College of Pharmacy, Kodhwa, Pune - 411048, India

Abstract


The present study deals with UV spectrophotometric method development and Validation for estimation of Tizanidine and Aceclofenac in bulk drug and tablet dosage form by absorption correction by interference method. The method is based on by using two wavelengths, 274 nm for aceclofenac and 318 nm for Tizanidine. The Linearity of Tizanidine and Aceclofenac was found to be in the range 0f 2-10 μg/ml and 5-25 μg/ml respectively. The % recovery of Tizanidine and Aceclofenac was found out to be 98-102 % respectively. The proposed method was validated as per ICH guidelines.

Keywords


Aceclofenac, Tizanidine, Absorption Correction Method.