Clinical Evaluation to Assess the Efficacy of Ethanolic Extract of Avocado Fruit on Diabetic Dyslipidemia Studied in STZ- Induced Experimental Albino Rats

In Diabetes mellitus, the insulin defect reflects in elevated gluconeogenic metabolite accumulation, which leads to excess acetyl Co-A storage, and, in turn, the acetyl Co-A acts as a precursor of lipids directly, and lipoprotein indirectly, synthesis. Thus, hyperlipidemia is an associated complication of diabetes mellitus. Recently, we have reported that ethanolic extract of Persea americana lowered the blood glucose and oxidative stress in diabetic rats. In this present study, the hypolipidemic effect of Persea americana fruit was investigated in streptozotocin-induced diabetic rats. Oral administration of fruit extract (300 mg/kg b.w.) for 30 days resulted in significant reduction in serum and tissue cholesterol, triglycerides, phospholipids and free fatty acids in STZ-diabetic rats. In addition to that, significant decrease in high density lipoprotein while significant increase in low density lipoprotein and very low density lipoprotein, were observed in diabetic rats, which were brought to near normal after 30 days of herbal extract treatment. The results obtained are comparable with glyclazide, a standard drug. Results of the present study indicate that the fruits of Avocado showed antihyperlipidemic effect in addition to its antidiabetic and free radical scavenging activity properties in type 2 diabetic rats.