Asian Journal of Research in Chemistry

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Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine Derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus


Affiliations
1 SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., India
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), India
3 Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), India
4 PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), India
     

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1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone&Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.

Keywords

Chalcones, 2-Amino Thio Phenol, Cyclisation, 1, 5-Benzothiazepines, Anti-Microbial Activity, Thieno [3, 2-d] Pyrimidine Core Ring.
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  • Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine Derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus

Abstract Views: 385  |  PDF Views: 1

Authors

Virupakshi Prabhakar
SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., India
Kondra Sudhakar Babu
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), India
L. K. Ravindranath
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), India
J. Latha
Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), India
B. Venkateswarlu
PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.), India

Abstract


1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone&Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.

Keywords


Chalcones, 2-Amino Thio Phenol, Cyclisation, 1, 5-Benzothiazepines, Anti-Microbial Activity, Thieno [3, 2-d] Pyrimidine Core Ring.

References